The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells
Open accessAbstract
Elevated blood levels of homocysteine are associated with atherosclerosis and thrombotic disease. We previously reported that treatment of cultured endothelial cells with homocysteine increased endogenous factor V activity by activation of the cofactor. Because endothelial cell-associated factor Va would be regulated by the protein C mechanism, the ability of homocysteine-treated arterial and venous endothelial cells to activate protein C was investigated. Both arterial and venous endothelial cells activated protein C; 0.6 mmol/L homocysteine reduced endothelial cell protein C activation by 12%. Maximal inhibition (90%) of protein C activation occurred with 7.5 to 10 mmol/L homocysteine after 6 to 9 hours of incubation. Metabolism of homocysteine was not accelerated by cultured endothelial cells. Investigation of the mechanism(s) by which homocysteine reduced protein C activation indicated that the metabolite did not induce an inhibitor to activated protein C, but in low concentrations acted as a competitive inhibitor to thrombin. These data suggest that perturbation of the vascular endothelial cell protein C mechanism by homocysteine may contribute to the thrombotic tendency seen in patients with elevated blood levels of this metabolite.
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Cites
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Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease
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Cited by
Homocysteine and Cardiovascular Disease
Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180
Homocysteine and Atherothrombosis
Welch, G. N., & Loscalzo, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804093381507 · Cited by 1,997
Hofmann, M. A., Lalla, E., Lu, Y., Gleason, M. R., Wolf, B. M., Tanji, N., Ferran, L. J., Kohl, B., Rao, V., Kisiel, W., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10588 · Cited by 529
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Metadata
- Authors
- Rodgers, G., & Conn, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1990-02-15
- Volume
- 75
- Issue
- 4
- Pages
- 895-901
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1557771952
- Cited by
- 398
- References
- 17
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. https://app.cochat.ai/papers/10.1182/blood.v75.4.895.895
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- Rodgers, G., & Conn, M. (1990). Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood. https://doi.org/10.1182/blood.v75.4.895.895
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
