The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Introduction of a Normal Human Chromosome 11 into a Wilms' Tumor Cell Line Controls Its Tumorigenic Expression
Abstract
The development of Wilms' tumor, a pediatric nephroblastoma, has been associated with a deletion in the p13 region of chromosome 11. The structure and function or functions of this deleted genetic material are unknown. The role of this deletion in the process of malignant transformation was investigated by introducing a normal human chromosome 11 into a Wilms' tumor cell line by means of the microcell transfer technique. These variant cells, derived by microcell hybridization, expressed similar transformed traits in culture as the parental cell line. Furthermore, expression of several proto-oncogenes by the parental cells was unaffected by the introduction of this chromosome. However, the ability of these cells to form tumors in nude mice was completely suppressed. Transfer of other chromosomes, namely X and 13, had no effect on the tumorigenicity of the Wilms' tumor cells. These studies provide support for the existence of genetic information on chromosome 11 which can control the malignant expression of Wilms' tumor cells.
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Cites
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Ruley, H. E. (1983) · Nature · doi:10.1038/304602a0 · Cited by 1,248
Cited by
Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,756
Tumour-suppressor activity of H19 RNA
Hao, Y., Crenshaw, T., Moulton, T., Newcomb, E., & Tycko, B. (1993) · Nature · doi:10.1038/365764a0 · Cited by 630
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor
Haber, D. A., Buckler, A. J., Glaser, T., Call, K. M., Pelletier, J., Sohn, R. L., Douglass, E. C., & Housman, D. E. (1990) · Cell · doi:10.1016/0092-8674(90)90690-g · Cited by 573
Church, S. L., Grant, J. W., Ridnour, L. A., Oberley, L. W., Swanson, P. E., Meltzer, P. S., & Trent, J. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.3113 · Cited by 473
TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer
Kuramochi, M., Fukuhara, H., Nobukuni, T., Kanbe, T., Maruyama, T., Ghosh, H. P., Pletcher, M., Isomura, M., Onizuka, M., Kitamura, T., et al. (2001) · Nature Genetics · doi:10.1038/86934 · Cited by 441
Metadata
- Authors
- Weissman, B. E., Saxon, P. J., Pasquale, S. R., Jones, G. R., Geiser, A. G., & Stanbridge, E. J.
- Venue
- Science
- Published
- 1987-04-10
- Volume
- 236
- Issue
- 4798
- Pages
- 175-180
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025615787
- Cited by
- 396
- References
- 3
- FWCI
- 19.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weissman, B. E., Saxon, P. J., Pasquale, S. R., Jones, G. R., Geiser, A. G., & Stanbridge, E. J. (1987). Introduction of a Normal Human Chromosome 11 into a Wilms' Tumor Cell Line Controls Its Tumorigenic Expression. Science. https://doi.org/10.1126/science.3031816
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