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Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit
Abstract
The interaction between receptors and guanine nucleotide binding (G) proteins leads to G protein activation and subsequent regulation of effector enzymes. The molecular basis of receptor-G protein interaction has been examined by using the ability of the G protein from rods (transducin) to cause a conformational change in rhodopsin as an assay. Synthetic peptides corresponding to two regions near the carboxyl terminus of the G protein α subunit, Glu 311 -Val 328 and Ile 340 -Phe 350 , compete with G protein for interaction with rhodopsin. Amino acid substitution studies show that Cys 321 is required for this effect. Ile 340 -Phe 350 and a modified peptide, acetyl-Glu 311 -Lys 329 -amide, mimic G protein effects on rhodopsin conformation, showing that these peptides bind to and stabilize the activated conformation of rhodopsin.
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Citations
Cited by
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Buck, L., & Axel, R. (1991) · Cell · doi:10.1016/0092-8674(91)90418-x · Cited by 4,987
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Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Crystal structure of opsin in its G-protein-interacting conformation
Scheerer, P., Park, J. H., Hildebrand, P. W., Kim, Y. J., Krauß, N., Choe, H.-W., Hofmann, K. P., & Ernst, O. P. (2008) · Nature · doi:10.1038/nature07330 · Cited by 1,059
Self-citationA G protein-coupled receptor at work: the rhodopsin model
Hofmann, K. P., Scheerer, P., Hildebrand, P. W., Choe, H.-W., Park, J. H., Heck, M., & Ernst, O. P. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.07.005 · Cited by 376
Self-citationRhodopsin: Insights from Recent Structural Studies
Sakmar, T. P., Menon, S. T., Marin, E. P., & Awad, E. S. (2002) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.31.082901.134348 · Cited by 240
Metadata
- Authors
- Hamm, H. E., Deretic, D., Arendt, A., Hargrave, P. A., Koenig, B., & Hofmann, K. P.
- Venue
- Science
- Published
- 1988-08-12
- Volume
- 241
- Issue
- 4867
- Pages
- 832-835
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015176049
- Cited by
- 498
- References
- 0
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamm, H. E., Deretic, D., Arendt, A., Hargrave, P. A., Koenig, B., & Hofmann, K. P. (1988). Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit. Science. https://doi.org/10.1126/science.3136547
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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