Cited by 4,987Olfactory and Sensory Function StudiesBiochemical Analysis and Sensing TechniquesIon Channels and Receptors

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

Open access
Buck, Linda, Axel, Richard·1991·Cell

Abstract

The mammalian olfactory system can recognize and discriminate a large number of different odorant molecules. The detection of chemically distinct odorants presumably results from the association of odorous ligands with specific receptors on olfactory sensory neurons. To address the problem of olfactory perception at a molecular level, we have cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium. The members of this novel gene family are likely to encode a diverse family of odorant receptors.

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Crossref · 10.1016/0092-8674(91)90418-x

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  • These genes are expressed in VSNs and are similar in apparent transmembrane organization to olfactory receptor genes, but differ in much of their DNA sequence.

    “These genes are expressed in VSNs and are similar in apparent transmembrane organization to olfactory receptor genes (Buck and Axel, 1991), but differ in much of their DNA sequence.”

    From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Buck and Axel, 1991

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Authors
Buck, L., & Axel, R.
Affiliations
  • Columbia University (US)
  • Howard Hughes Medical Institute (US)
Venue
Cell
Publisher
Elsevier BV
Published
1991-04
Volume
65
Issue
1
Pages
175-187
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2097186487
Cited by
4,987
References
45
Citations by year
2026: 90 · 2025: 176 · 2024: 185 · 2023: 162 · 2022: 165 · 2021: 150 · 2020: 207 · 2019: 163 · 2018: 149 · 2017: 171 · 2016: 182 · 2015: 212 · 2014: 176 · 2013: 186 · 2012: 159
FWCI
60.14
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P01-CA23767, P01CA023767)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
olfactory receptors, gene family, olfactory sensory neurons, olfactory epithelium, seven-transmembrane proteins, odorant recognition, olfaction, gene cloning, ligand-gated receptors
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA, Biological Evolution, Multigene Family, Membrane Proteins, Molecular Sequence Data, Olfactory Pathways, Organ Specificity, Protein Conformation, Rats, Inbred Strains, Sensory Receptor Cells, Smell, Blotting, Southern, Blotting, Northern, Gene Expression, Polymerase Chain Reaction, Rats

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