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Cited by 269

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Presence of Laminin Receptors in Staphylococcus aureus

Lopes, J. D., dos Reis, M., Brentani, R. R.·1985·Science

Abstract

A characteristic feature of infection by Staphylococcus aureus is bloodstream invasion and widespread metastatic abscess formation. The ability to extravasate, which entails crossing the vascular basement membrane, appears to be critical for the organism's pathogenicity. Extravasation by normal and neoplastic mammalian cells has been correlated with the presence of specific cell surface receptors for the basement membrane glycoprotein laminin. Similar laminin receptors were found in Staphylococcus aureus but not in Staphylococcus epidermidis , a noninvasive pathogen. There were about 100 binding sites per cell, with an apparent binding affinity of 2.9 nanomolar. The molecular weight of the receptor was 50,000 and p I was 4.2. Eukaryotic laminin receptors were visualized by means of the binding of S. aureus in the presence of laminin. Prokaryotic and eukaryotic invasive cells might utilize similar, if not identical, mechanisms for invasion.

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Crossref · 10.1126/science.3160113

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Metadata

Authors
Lopes, J. D., dos Reis, M., & Brentani, R. R.
Venue
Science
Published
1985-07-19
Volume
229
Issue
4710
Pages
275-277
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1976613562
Cited by
269
References
22
FWCI
12.84
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Presence of Laminin Receptors in Staphylococcus aureus. https://app.cochat.ai/papers/10.1126/science.3160113
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Lopes, J. D., dos Reis, M., & Brentani, R. R. (1985). Presence of Laminin Receptors in Staphylococcus aureus. Science. https://doi.org/10.1126/science.3160113

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.