The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Presence of Laminin Receptors in Staphylococcus aureus
Abstract
A characteristic feature of infection by Staphylococcus aureus is bloodstream invasion and widespread metastatic abscess formation. The ability to extravasate, which entails crossing the vascular basement membrane, appears to be critical for the organism's pathogenicity. Extravasation by normal and neoplastic mammalian cells has been correlated with the presence of specific cell surface receptors for the basement membrane glycoprotein laminin. Similar laminin receptors were found in Staphylococcus aureus but not in Staphylococcus epidermidis , a noninvasive pathogen. There were about 100 binding sites per cell, with an apparent binding affinity of 2.9 nanomolar. The molecular weight of the receptor was 50,000 and p I was 4.2. Eukaryotic laminin receptors were visualized by means of the binding of S. aureus in the presence of laminin. Prokaryotic and eukaryotic invasive cells might utilize similar, if not identical, mechanisms for invasion.
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Cited by
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Clinical presentation and treatment of orthopaedic implant‐associated infection
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Bacterial proteins binding to the mammalian extracellular matrix
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Metadata
- Authors
- Lopes, J. D., dos Reis, M., & Brentani, R. R.
- Venue
- Science
- Published
- 1985-07-19
- Volume
- 229
- Issue
- 4710
- Pages
- 275-277
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976613562
- Cited by
- 269
- References
- 22
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- closed
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