The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Clinical presentation and treatment of orthopaedic implant‐associated infection
Abstract
Orthopaedic implants are highly susceptible to infection. The aims of treatment of infection associated with internal fixation devices are fracture consolidation and prevention of chronic osteomyelitis. Complete biofilm eradication is not the primary goal, as remaining adherent microorganisms can be removed with the device after fracture consolidation. By contrast, in periprosthetic joint infection (PJI), biofilm elimination is required. Surgical treatment of PJI includes debridement with retention, one‐ or two‐stage exchange and removal without reimplantation. In addition, prolonged antibiotic treatment, preferably with an agent that is effective against biofilm bacteria, is required. Rifampicin is an example of an antibiotic with these properties against staphylococci. However, to avoid the emergence of resistance, rifampicin must always be combined with another antimicrobial agent. With this novel treatment approach, orthopaedic implant‐associated infection is likely to be eradicated in up to 80–90% of patients. Because most antibiotics have a limited effect against biofilm infections, novel prophylactic and therapeutic options are needed. Surface coating with antimicrobial peptides that reduce bacterial attachment and biofilm formation can potentially prevent implant‐associated infection. In addition, quorum‐sensing inhibitors are a novel therapeutic option against biofilm infections.
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Zimmerli, W., Trampuz, A., & Ochsner, P. E. (2004) · New England Journal of Medicine · doi:10.1056/nejmra040181 · Cited by 3,116
Self-citationHoran, T. C., Gaynes, R. P., Martone, W. J., Jarvis, W. R., & Grace Emori, T. (1992) · American Journal of Infection Control · doi:10.1016/s0196-6553(05)80201-9 · Cited by 2,609
Osmon, D. R., Berbari, E. F., Berendt, A. R., Lew, D., Zimmerli, W., Steckelberg, J. M., Rao, N., Hanssen, A., & Wilson, W. R. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cis803 · Cited by 2,266
Self-citationPrinciples and Practice of Infectious Diseases
Larson, H. E. (1980) · Journal of Clinical Pathology · doi:10.1136/jcp.33.9.907-a · Cited by 1,276
Zimmerli, W. (1998) · JAMA · doi:10.1001/jama.279.19.1537 · Cited by 1,079
Self-citationInfection Burden for Hip and Knee Arthroplasty in the United States
Kurtz, S. M., Lau, E., Schmier, J., Ong, K. L., Zhao, K., & Parvizi, J. (2008) · The Journal of Arthroplasty · doi:10.1016/j.arth.2007.10.017 · Cited by 1,006
Osmon, D. R., Berbari, E. F., Berendt, A. R., Lew, D., Zimmerli, W., Steckelberg, J. M., Rao, N., Hanssen, A., & Wilson, W. R. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cis966 · Cited by 924
Self-citationRisk Factors for Prosthetic Joint Infection: Case‐Control Study
Berbari, E. F., Hanssen, A. D., Duffy, M. C., Steckelberg, J. M., Ilstrup, D. M., Harmsen, W. S., & Osmon, D. R. (1998) · Clinical Infectious Diseases · doi:10.1086/514991 · Cited by 840
Infection Associated with Prosthetic Joints
Del Pozo, J. L., & Patel, R. (2009) · New England Journal of Medicine · doi:10.1056/nejmcp0905029 · Cited by 816
A Comparison of Two Antimicrobial-Impregnated Central Venous Catheters
Darouiche, R. O., Raad, I. I., Heard, S. O., Thornby, J. I., Wenker, O. C., Gabrielli, A., Berg, J., Khardori, N., Hanna, H., Hachem, R., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400101 · Cited by 804
Cited by
Infection after fracture fixation: Current surgical and microbiological concepts
Metsemakers, W. J., Kuehl, R., Moriarty, T. F., Richards, R. G., Verhofstad, M. H. J., Borens, O., Kates, S., & Morgenstern, M. (2018) · Injury · doi:10.1016/j.injury.2016.09.019 · Cited by 544
Prevention and treatment of Staphylococcus aureus biofilms
Bhattacharya, M., Wozniak, D. J., Stoodley, P., & Hall-Stoodley, L. (2015) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2015.1100533 · Cited by 265
Biodegradable bone implants as a new hope to reduce device-associated infections-a systematic review
Paiva, J. C. C., Oliveira, L., Vaz, M. F., & Costa-de-Oliveira, S. (2022) · Bioengineering · doi:10.3390/bioengineering9080409 · Cited by 53
Metadata
- Authors
- Zimmerli, W.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2014-07-14
- Volume
- 276
- Issue
- 2
- Pages
- 111-119
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2000238227
- Cited by
- 481
- References
- 62
- FWCI
- 23.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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