The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos
Abstract
Control of growth and differentiation during mammalian embryogenesis may be regulated by growth factors from embryonic or maternal sources. With the use of single-cell messenger RNA phenotyping, the simultaneous expression of growth factor transcripts in single or small numbers of preimplantation mouse embryos was examined. Transcripts for platelet-derived growth factor A chain (PDGF-A), transforming growth factor (TGF)-α, and TGF-β1, but not for four other growth factors, were found in whole blastocysts. TGF-α, TGF-β1, and PDGF antigens were detected in blastocysts by immunocytochemistry. Both PDGF-A and TGF-α were detected as maternal transcripts in the unfertilized ovulated oocyte, and again in blastocysts. TGF-β1 transcripts appeared only after fertilization. The expression of a subset of growth factors in mouse blastocysts suggests a role for these factors in the growth and differentiation of early mammalian embryos.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Cited by
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029
PLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 940
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81270-2 · Cited by 864
Platelet-derived growth factor: mechanism of action and possible in vivo function.
Heldin, C. H., & Westermark, B. (1990) · Cell Regulation · doi:10.1091/mbc.1.8.555 · Cited by 486
Metadata
- Authors
- Rappolee, D. A., Brenner, C. A., Schultz, R., Mark, D., & Werb, Z.
- Venue
- Science
- Published
- 1988-09-30
- Volume
- 241
- Issue
- 4874
- Pages
- 1823-1825
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975729483
- Cited by
- 679
- References
- 1
- FWCI
- 25.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rappolee, D. A., Brenner, C. A., Schultz, R., Mark, D., & Werb, Z. (1988). Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos. Science. https://doi.org/10.1126/science.3175624
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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