The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Xeroderma Pigmentosum Group E Cells Lack a Nuclear Factor That Binds to Damaged DNA
Abstract
The disease xeroderma pigmentosum is characterized by deficient repair of damaged DNA. Fusions of cells from different patients have defined nine genetic complementation groups (A through I), implying that DNA repair in humans involves multiple gene products. In this report, an extension of the gel electrophoresis binding assay was used to identify at least one nuclear factor that (i) bound to DNA damaged by ultraviolet radiation or the antitumor drug cisplatin, but (ii) was notably absent in cells from complementation group E. Therefore, the factor appears to participate in a versatile DNA repair pathway at the stage of binding and recognition.
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Cited by
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
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InfluentialUnderstanding nucleotide excision repair and its roles in cancer and ageing
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Mammalian DNA nucleotide excision repair reconstituted with purified protein components
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Metadata
- Authors
- Chu, G., & Chang, E.
- Venue
- Science
- Published
- 1988-10-28
- Volume
- 242
- Issue
- 4878
- Pages
- 564-567
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008561915
- Cited by
- 416
- References
- 16
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chu, G., & Chang, E. (1988). Xeroderma Pigmentosum Group E Cells Lack a Nuclear Factor That Binds to Damaged DNA. Science. https://doi.org/10.1126/science.3175673
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
