The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Structure of the Lambda Complex at 2.5 Å Resolution: Details of the Repressor-Operator Interactions
Abstract
The crystal structure of a complex containing the DNA-binding domain of lambda repressor and a lambda operator site was determined at 2.5 Å resolution and refined to a crystallographic R factor of 24.2 percent. The complex is stabilized by an extensive network of hydrogen bonds between the protein and the sugar-phosphate backbone. Several side chains form hydrogen bonds with sites in the major groove, and hydrophobic contacts also contribute to the specificity of binding. The overall arrangement of the complex is quite similar to that predicted from earlier modeling studies, which fit the protein dimer against linear B-form DNA. However, the cocrystal structure reveals important side chain-side chain interactions that were not predicted from the modeling or from previous genetic and biochemical studies.
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Cites
Mutations Defining the Operator-binding Sites of Bacteriophage Repressor
Nelson, H. C. M., Hecht, M. H., & Sauer, R. T. (1983) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1983.047.01.052 · Cited by 49
Cited by
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,551
A structural taxonomy of DNA-binding domains
Harrison, S. C. (1991) · Nature · doi:10.1038/353715a0 · Cited by 608
Klemm, J. D., Rould, M. A., Aurora, R., Herr, W., & Pabo, C. O. (1994) · Cell · doi:10.1016/0092-8674(94)90231-3 · Cited by 506
Self-citationStructure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance
Hinrichs, W., Kisker, C., Düvel, M., Müller, A., Tovar, K., Hillen, W., & Saenger, W. (1994) · Science · doi:10.1126/science.8153629 · Cited by 408
Role of the hydrophobic effect in stability of site-specific protein-DNA complexes
Ha, J.-H., Spolar, R. S., & Record, M. T. (1989) · Journal of Molecular Biology · doi:10.1016/0022-2836(89)90608-6 · Cited by 386
Metadata
- Authors
- Jordan, S. R., & Pabo, C. O.
- Venue
- Science
- Published
- 1988-11-11
- Volume
- 242
- Issue
- 4880
- Pages
- 893-899
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026598193
- Cited by
- 492
- References
- 1
- FWCI
- 70.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jordan, S. R., & Pabo, C. O. (1988). Structure of the Lambda Complex at 2.5 Å Resolution: Details of the Repressor-Operator Interactions. Science. https://doi.org/10.1126/science.3187530
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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