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A Novel Gene of HIV-1, vpu , and Its 16-Kilodalton Product
Abstract
A 16-kilodalton protein expressed in cells producing the human immunodeficiency virus (HIV-1) was identified as the gene product of the vpu open reading frame. When expressed in vitro, the 81-amino acid vpu protein reacted with about one-third of the serum samples from AIDS patients that were tested, indicating that the vpu open reading frame is expressed in vivo as well. Introduction of a frame-shift mutation into the vpu open reading frame did not significantly interfere with expression of the major viral proteins in a transient expression system. However, a five- to tenfold reduction in progeny virions was observed after the infection of T lymphocytes with the mutant virus. These data suggest that the vpu gene product is required for efficient virus replication and may have a role in assembly or maturation of progeny virions.
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Cited by
Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4
Willey, R. L., Maldarelli, F., Martin, M. A., & Strebel, K. (1992) · Journal of Virology · doi:10.1128/jvi.66.12.7193-7200.1992 · Cited by 554
Self-citationStevenson, M. (2003) · Nature Medicine · doi:10.1038/nm0703-853 · Cited by 441
Gonzalez, M. E., & Carrasco, L. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00780-4 · Cited by 359
Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein
Strebel, K., Klimkait, T., Maldarelli, F., & Martin, M. A. (1989) · Journal of Virology · doi:10.1128/jvi.63.9.3784-3791.1989 · Cited by 275
Self-citationCell–cell transmission allows human T-lymphotropic virus 1 to circumvent tetherin restriction
Ilinskaya, A., Derse, D., Hill, S., Princler, G., & Heidecker, G. (2013) · Virology · doi:10.1016/j.virol.2012.11.012 · Cited by 30
Metadata
- Authors
- Strebel, K., Klimkait, T., & Martin, M. A.
- Venue
- Science
- Published
- 1988-09-02
- Volume
- 241
- Issue
- 4870
- Pages
- 1221-1223
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984125372
- Cited by
- 447
- References
- 0
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Strebel, K., Klimkait, T., & Martin, M. A. (1988). A Novel Gene of HIV-1, vpu , and Its 16-Kilodalton Product. Science. https://doi.org/10.1126/science.3261888
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