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Cited by 1,459

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Mechanism of Carbon Isotope Fractionation Associated with Lipid Synthesis

DeNiro, Michael J., Epstein, Samuel·1977·Science

Abstract

The low carbon-13/carbon-12 ratio of lipids is shown to result from isotopic fractionation during the oxidation of pyruvate to acetyl coenzyme A. In vitro analysis of the kinetic isotope effects of this reaction indicates that there will be a large, temperature-dependent difference in the carbon-13/carbon-12 ratio between the methyl and carbonyl carbon atoms of acetyl coenzyme A and between those carbon atoms of lipid components which derive from them.

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Metadata

Authors
DeNiro, M. J., & Epstein, S.
Venue
Science
Published
1977-07-15
Volume
197
Issue
4300
Pages
261-263
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2091699432
Cited by
1,459
References
2
FWCI
3.76
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Mechanism of Carbon Isotope Fractionation Associated with Lipid Synthesis. https://app.cochat.ai/papers/10.1126/science.327543
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DeNiro, M. J., & Epstein, S. (1977). Mechanism of Carbon Isotope Fractionation Associated with Lipid Synthesis. Science. https://doi.org/10.1126/science.327543

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.