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Some Thoughts on Clinical Trials, Especially Problems of Multiplicity
Abstract
Problems of statistical and conceptual design of experiments are exacerbated by ethical issues in many, if not most, clinical trials. Statutory requirements of demonstrated effectiveness are far from being clearly resolved—either qualitatively or quantitatively. Ethics, bolstered by informed consent, are likely to keep us from ever learning the answer to many questions. Unbalanced boundaries, focusing-down designs, historical controls, and not-very-sequential designs are among the possible consequences.
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Research works printed but not linked: 10
- Tukey J. W. presented at the Birnbaum Memorial Symposium 27 May (1977).
- ARMITAGE, P, REPEATED SIGNIFICANCE TESTS ON ACCUMULATING DATA, JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-GENERAL 132: 235 (1969). · DOI · Paper page
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- 10.1126/science.333585 · DOI
- McPherson, C. K., Journal of the Royal Statistical Society. Series A (General) 134: 15 (1971). · DOI
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- PETO, R, DESIGN AND ANALYSIS OF RANDOMIZED CLINICAL-TRIALS REQUIRING PROLONGED OBSERVATION OF EACH PATIENT .2. ANALYSIS AND EXAMPLES, BRITISH JOURNAL OF CANCER 35: 1 (1977). · DOI · Paper page
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Cited by
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gotzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010) · BMJ · doi:10.1136/bmj.c869 · Cited by 8,883
What's wrong with Bonferroni adjustments
Perneger, T. V. (1998) · BMJ · doi:10.1136/bmj.316.7139.1236 · Cited by 5,900
The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration
Altman, D. G., Schulz, K. F., Moher, D., Egger, M., Davidoff, F., Elbourne, D., Gøtzsche, P. C., Lang, T., & for the CONSORT Group (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-8-200104170-00012 · Cited by 3,835
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gøtzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2012) · International Journal of Surgery · doi:10.1016/j.ijsu.2011.10.001 · Cited by 2,345
On the adaptive control of the false discovery rate in multiple testing with independent statistics
Benjamini, Y., & Hochberg, Y. (2000) · Journal of Educational and Behavioral Statistics · doi:10.3102/10769986025001060 · Cited by 2,015
Metadata
- Authors
- Tukey, J. W.
- Venue
- Science
- Published
- 1977-11-18
- Volume
- 198
- Issue
- 4318
- Pages
- 679-684
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026250491
- Cited by
- 479
- References
- 0
- FWCI
- 24.87
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
