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Glycosyl-Phosphatidylinositol Moiety That Anchors Trypanosoma brucei Variant Surface Glycoprotein to the Membrane
Abstract
Two forms of protein-membrane anchor have been described for the externally disposed glycoproteins of eukaryotic plasma membranes; namely, the hydrophobic transmembrane polypeptide and the complex glycosylphosphatidylinositol (G-PI) moiety. The chemical structures of the major species of G-PI anchors found on a single variant surface glycoprotein (VSG) of the parasitic protozoan Trypanosoma brucei were determined by a combination of nuclear magnetic resonance spectroscopy, mass spectrometry, chemical modification, and exoglycosidase digestions. The G-PI anchor was found to be heterogeneous with respect to monosaccharide sequence, and several novel glycosidic linkages were present. The results are pertinent to the mechanism of the biosynthesis of G-PI anchors.
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Cited by
Navarre, W. W., & Schneewind, O. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.1.174-229.1999 · Cited by 1,391
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Aimanianda, V., Bayry, J., Bozza, S., Kniemeyer, O., Perruccio, K., Elluru, S. R., Clavaud, C., Paris, S., Brakhage, A. A., Kaveri, S. V., et al. (2009) · Nature · doi:10.1038/nature08264 · Cited by 792
Antigenic variation in African trypanosomes
Horn, D. (2014) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2014.05.001 · Cited by 332
GPI Transamidase and GPI anchored proteins: Oncogenes and biomarkers for cancer
Gamage, D. G., & Hendrickson, T. L. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.831024 · Cited by 63
ILG, T., HARBECKE, D., WIESE, M., & OVERATH, P. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18283.x · Cited by 62
Metadata
- Authors
- Ferguson, M. A. J., Homans, S. W., Dwek, R. A., & Rademacher, T. W.
- Venue
- Science
- Published
- 1988-02-12
- Volume
- 239
- Issue
- 4841
- Pages
- 753-759
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971942838
- Cited by
- 705
- References
- 0
- FWCI
- 52.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ferguson, M. A. J., Homans, S. W., Dwek, R. A., & Rademacher, T. W. (1988). Glycosyl-Phosphatidylinositol Moiety That Anchors Trypanosoma brucei Variant Surface Glycoprotein to the Membrane. Science. https://doi.org/10.1126/science.3340856
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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