Stopping Alzheimer's Before It Starts
Abstract
Three new clinical trials expected to begin next year will attempt to prevent dementia by treating people at risk for the disease before they develop symptoms.
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5XFAD mice at 8 months of age, at which point significant neuronal loss occurs, were used.
“To investigate whether TN-PTBP1 could regenerate neurons in AD mice and improve their memory and cognitive skills, 5XFAD mice at 8 months of age, at which point significant neuronal loss occurs, were used.36,37”
From Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration (2026) · cites this paper as [36]
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Defeating Alzheimer's disease and other dementias: a priority for European science and society
Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676 · see citing works
Shi, M., Chu, F., Zhu, F., & Zhu, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.870517 · Cited by 275 · see citing works
Jiang, Y., Li, K., Li, X., Xu, L., & Yang, Z. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109452 · Cited by 154 · see citing works
Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer’s Disease
Vyas, Y., Montgomery, J. M., & Cheyne, J. E. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00266 · Cited by 66 · see citing works
Illouz, T., Nicola, R., Ben-Shushan, L., Madar, R., Biragyn, A., & Okun, E. (2021) · Communications Biology · doi:10.1038/s42003-021-01851-6 · Cited by 21 · see citing works
Liu, H.-J., Wang, M., Wang, Y., Shi, S., Hu, X., Zhang, D.-B., Fan, D., Mintzer, J., & Xu, P. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100158 · Cited by 13 · see citing works
Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration
Wang, M., VanderVeen, B., Xu, Z. A., Xu, Y., Mintzer, J., Murphy, A., Zhang, Q., & Xu, P. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2026.100575
- Authors
- Miller, G.
- Corresponding author
- Miller, Greg
- Venue
- Science
- Published
- 2012-08-17
- Volume
- 337
- Issue
- 6096
- Pages
- 790-792
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042466570
- Cited by
- 73
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 15 · 2013: 21 · 2012: 4
- Type
- other
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- Alzheimer's disease, dementia prevention, early intervention, clinical trials, disease risk
- MeSH terms
- Adult, Alzheimer Disease, Antibodies, Monoclonal, Child, Clinical Trials as Topic, DNA Mutational Analysis, Female, Genetic Carrier Screening, Humans, Information Services, Male, Pedigree, Primary Prevention, Risk, Age of Onset, Genetic Predisposition to Disease, Apolipoprotein E4, Antibodies, Monoclonal, Humanized
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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