The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers
Abstract
Mutational inactivation of the retinoblastoma susceptibility (RB) gene, a recessive cancer gene, has been implicated in the genesis of retinoblastoma and certain other human neoplasms. This gene is now shown to be inactivated in two of nine human breast cancer cell lines examined. The RB gene of one cell line had a homozygous internal duplication of a 5-kilobase region containing exons 5 and 6. The RB messenger RNA transcript was correspondingly lengthened, and its translation was probably terminated prematurely due to a shifted reading frame. The other cell line had a homozygous deletion of the RB gene that removed the entire gene beyond exon 2. The RB gene product, pp110 RB , was not detectable in either cell line by immunoprecipitation with specific antibodies. These findings are significant in relation to proposed genetic mechanisms of breast cancer formation.
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Citations
Cites
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948
Cited by
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13
Wooster, R., Neuhausen, S. L., Mangion, J., Quirk, Y., Ford, D., Collins, N., Nguyen, K., Seal, S., Tran, T., Averill, D., et al. (1994) · Science · doi:10.1126/science.8091231 · Cited by 1,924
Call, K. M., Glaser, T., Ito, C. Y., Buckler, A. J., Pelletier, J., Haber, D. A., Rose, E. A., Kral, A., Yeger, H., Lewis, W. H., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90601-a · Cited by 1,876
Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,756
Metadata
- Authors
- Lee, E. Y.-H. P., To, H., Shew, J.-Y., Bookstein, R., Scully, P., & Lee, W.-H.
- Venue
- Science
- Published
- 1988-07-08
- Volume
- 241
- Issue
- 4862
- Pages
- 218-221
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086322317
- Cited by
- 581
- References
- 1
- FWCI
- 35.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, E. Y.-H. P., To, H., Shew, J.-Y., Bookstein, R., Scully, P., & Lee, W.-H. (1988). Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers. Science. https://doi.org/10.1126/science.3388033
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