The DOI matches its Crossref record.
The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5
Abstract
The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.
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Citations
Cited by
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Molecular Genetics of Colorectal Cancer
Fearon, E. R. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130235 · Cited by 1,805
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
Localization of a susceptibility locus for schizophrenia on chromosome 5
Sherrington, R., Brynjolfsson, J., Petursson, H., Potter, M., Dudleston, K., Barraclough, B., Wasmuth, J., Dobbs, M., & Gurling, H. (1988) · Nature · doi:10.1038/336164a0 · Cited by 616
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Metadata
- Authors
- Leppert, M., Dobbs, M., Scambler, P., O'Connell, P., Nakamura, Y., Stauffer, D., Woodward, S., Burt, R., Hughes, J., Gardner, E., Lathrop, M., Wasmuth, J., Lalouel, J.-M., & White, R.
- Venue
- Science
- Published
- 1987-12-04
- Volume
- 238
- Issue
- 4832
- Pages
- 1411-1413
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058403714
- Cited by
- 674
- References
- 0
- FWCI
- 49.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5. https://app.cochat.ai/papers/10.1126/science.3479843
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- Leppert, M., Dobbs, M., Scambler, P., O'Connell, P., Nakamura, Y., Stauffer, D., Woodward, S., Burt, R., Hughes, J., Gardner, E., Lathrop, M., Wasmuth, J., Lalouel, J.-M., & White, R. (1987). The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5. Science. https://doi.org/10.1126/science.3479843
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
