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Vasoconstriction: A New Activity for Platelet-Derived Growth Factor
Abstract
Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells that has been implicated in the pathogenesis of atherosclerosis. The potential role of PDGF in the altered vasoreactivity of atherosclerotic vessels has been studied through an examination of its effects on contractility in the rat aorta. PDGF caused a concentration-dependent contraction of aortic strips and was significantly more potent on a molar basis than the classic vasoconstrictor peptide angiotensin II. Furthermore, PDGF increased the cytosolic free calcium concentration in cultured rat aortic smooth muscle cells. These observations suggest a new biological activity for PDGF that may contribute to the enhanced vasoreactivity of certain atherosclerotic vessels.
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Citations
Cited by
PLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 940
The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation
Munro, J. M., & Cotran, R. S. (1989) · Pathology Reviews · 1989 · doi:10.1007/978-1-4612-4502-5_10 · Cited by 698
Resnick, N., Collins, T., Atkinson, W., Bonthron, D. T., Dewey, C. F., & Gimbrone, M. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4591 · Cited by 631
Self-citationTwo Classes of PDGF Receptor Eecognize Different Isoforms of PDGF
Hart, C. E., Forstrom, J. W., Kelly, J. D., Seifert, R. A., Smith, R. A., Ross, R., Murray, M. J., & Bowen-Pope, D. F. (1988) · Science · doi:10.1126/science.2836952 · Cited by 580
Recombinant Gene Expression in Vivo Within Endothelial Cells of the Arterial Wall
Nabel, E. G., Plautz, G., Boyce, F. M., Stanley, J. C., & Nabel, G. J. (1989) · Science · doi:10.1126/science.2499928 · Cited by 441
Metadata
- Authors
- Berk, B. C., Alexander, R. W., Brock, T. A., Gimbrone, M. A., & Webb, R. C.
- Venue
- Science
- Published
- 1986-04-04
- Volume
- 232
- Issue
- 4746
- Pages
- 87-90
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965526093
- Cited by
- 432
- References
- 0
- FWCI
- 46.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Berk, B. C., Alexander, R. W., Brock, T. A., Gimbrone, M. A., & Webb, R. C. (1986). Vasoconstriction: A New Activity for Platelet-Derived Growth Factor. Science. https://doi.org/10.1126/science.3485309
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
