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Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF
Abstract
Previous studies involving platelet-derived growth factor (PDGF) have been based on the premise that a single cell-surface receptor binds all three isoforms of PDGF (AA, BB, and AB). It is now shown that two populations of PDGF receptor exist and can be distinguished by their ligand binding specificity. The B receptor binds only the BB dimer, whereas the A/B receptor binds AA, BB, and AB dimers. Human dermal fibroblasts appear to express seven times as much B receptor as A/B receptor. The B receptor is responsible for most PDGF receptor phosphorylation.
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Citations
Cited by
G 1 Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182
The SIF binding element confers sis/PDGF inducibility onto the c‐fos promoter.
Wagner, B. J., Hayes, T. E., Hoban, C. J., & Cochran, B. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07898.x · Cited by 592
Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis
Ross, R., Masuda, J., Raines, E. W., Gown, A. M., Katsuda, S., Sasahara, M., Malden, L. T., Masuko, H., & Sato, H. (1990) · Science · doi:10.1126/science.2343305 · Cited by 574
Self-citation(1992) · PubMed · Cited by 383
Sano, H., Sudo, T., Yokode, M., Murayama, T., Kataoka, H., Takakura, N., Nishikawa, S., Nishikawa, S.-I., & Kita, T. (2001) · Circulation · doi:10.1161/01.cir.103.24.2955 · Cited by 169
Metadata
- Authors
- Hart, C. E., Forstrom, J. W., Kelly, J. D., Seifert, R. A., Smith, R. A., Ross, R., Murray, M. J., & Bowen-Pope, D. F.
- Venue
- Science
- Published
- 1988-06-10
- Volume
- 240
- Issue
- 4858
- Pages
- 1529-1531
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2056557043
- Cited by
- 580
- References
- 0
- FWCI
- 22.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hart, C. E., Forstrom, J. W., Kelly, J. D., Seifert, R. A., Smith, R. A., Ross, R., Murray, M. J., & Bowen-Pope, D. F. (1988). Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF. Science. https://doi.org/10.1126/science.2836952
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
