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Production of Immunoglobulin Isotypes by Ly-1 + B Cells in Viable Motheaten and Normal Mice
Abstract
Almost all B cells in autoimmune mice with the viable motheaten ( me v ) mutation express the Ly-1 cell surface antigen, which marks a minor population of B cells constituting a separate lineage in normal mice. Immunoglobulins primarily of the M and G3 classes, which in both normal and me v mice contain high levels of lambda light chain, are produced in excess in me v mice. These and other observations suggest that the development of B cells that express Ly-1 is regulated independently from the development of B cells that do not express Ly-1. B cells bearing the Ly-1 surface antigen may play specialized roles in the normal immune system and in autoimmunity by regulating other B cells via lymphokines, by producing antibodies to self and certain foreign antigens, and by preferentially secreting immunoglobulin M and immunoglobulin G3.
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Cited by
Shultz, L. D., Schweitzer, P. A., Rajan, T. V., Yi, T., Ihle, J. N., Matthews, R. J., Thomas, M. L., & Beier, D. R. (1993) · Cell · doi:10.1016/0092-8674(93)90369-2 · Cited by 581
Self-citationA Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP
Doody, G. M., Justement, L. B., Delibrias, C. C., Matthews, R. J., Lin, J., Thomas, M. L., & Fearon, D. T. (1995) · Science · doi:10.1126/science.7618087 · Cited by 538
Chan, V. W. F., Meng, F., Soriano, P., DeFranco, A. L., & Lowell, C. A. (1997) · Immunity · doi:10.1016/s1074-7613(00)80511-7 · Cited by 451
Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene
Wo Tsui, H., Siminovitch, K. A., de Souza, L., & Tsui, F. W. L. (1993) · Nature Genetics · doi:10.1038/ng0693-124 · Cited by 441
Bories, J.-C., Willerford, D. M., Grévin, D., Davidson, L., Camus, A., Martin, P., Stéhelin, D., & Alt, F. W. (1995) · Nature · doi:10.1038/377635a0 · Cited by 317
Metadata
- Authors
- Sidman, C. L., Shultz, L. D., Hardy, R. R., Hayakawa, K., & Herzenberg, L. A.
- Venue
- Science
- Published
- 1986-06-13
- Volume
- 232
- Issue
- 4756
- Pages
- 1423-1425
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044485561
- Cited by
- 289
- References
- 0
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sidman, C. L., Shultz, L. D., Hardy, R. R., Hayakawa, K., & Herzenberg, L. A. (1986). Production of Immunoglobulin Isotypes by Ly-1 + B Cells in Viable Motheaten and Normal Mice. Science. https://doi.org/10.1126/science.3487115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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