The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen
Abstract
The initial event in the infection of human T lymphocytes, macrophages, and other cells by human immunodeficiency virus (HIV-1) is the attachment of the HIV-1 envelope glycoprotein gp120 to its cellular receptor, CD4. As a step toward designing antagonists of this binding event, soluble, secreted forms of CD4 were produced by transfection of mammalian cells with vectors encoding versions of CD4 lacking its transmembrane and cytoplasmic domains. The soluble CD4 so produced binds gp120 with an affinity and specificity comparable to intact CD4 and is capable of neutralizing the infectivity of HIV-1. These studies reveal that the high-affinity CD4-gp120 interaction does not require other cell or viral components and may establish a novel basis for therapeutic intervention in the acquired immune deficiency syndrome (AIDS).
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Cites
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The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
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Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes
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Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein
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Cited by
Banda, N. K., Bernier, J., Kurahara, D. K., Kurrle, R., Haigwood, N., Sekaly, R. P., & Finkel, T. H. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.4.1099 · Cited by 668
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Wyatt, R., Moore, J., Accola, M., Desjardin, E., Robinson, J., & Sodroski, J. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5723-5733.1995 · Cited by 417
A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor
Bates, P., Young, J. A. T., & Varmus, H. E. (1993) · Cell · doi:10.1016/0092-8674(93)90726-7 · Cited by 355
Moore, J. P., McKeating, J. A., Huang, Y. X., Ashkenazi, A., & Ho, D. D. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.235-243.1992 · Cited by 284
Metadata
- Authors
- Smith, D. H., Byrn, R. A., Marsters, S. A., Gregory, T., Groopman, J. E., & Capon, D. J.
- Venue
- Science
- Published
- 1987-12-18
- Volume
- 238
- Issue
- 4834
- Pages
- 1704-1707
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015349792
- Cited by
- 485
- References
- 25
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Smith, D. H., Byrn, R. A., Marsters, S. A., Gregory, T., Groopman, J. E., & Capon, D. J. (1987). Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen. Science. https://doi.org/10.1126/science.3500514
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
