The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Regulation by Growth Hormone of Number of Chondrocytes Containing IGF-I in Rat Growth Plate
Abstract
Whether growth hormone stimulates longitudinal bone growth by a direct effect at the site of the growth plate or indirectly by increasing the concentration of circulating somatomedins (insulin-like growth factors) has been the subject of controversy. Immunohistochemical methods were used to explore the localization and distribution of insulin-like growth factor I (IGF-I) immunoreactivity in the epiphyseal growth plate of the proximal tibia of male rats. Cells in the proliferative zone of the growth plate of normal rats exhibited a bright immunofluorescence, whereas cells in the germinal and hypertrophic zones stained only weakly. In rats subjected to hypophysectomy, the number of fluorescent cells was markedly reduced. When the hypophysectomized rats were treated with growth hormone, either systemically or at the site of the growth plate, the number of IGF-I-immunoreactive cells in the proliferative zone was increased. The results show that IGF-I is produced in proliferative chondrocytes in the growth plate and that the number of IGF-I-containing cells is directly regulated by growth hormone. These findings suggest that IGF-I has a specific role in the clonal expansion of differentiated chondrocytes and exerts its function locally through autocrine or paracrine mechanisms.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,385
A simple method of reducing the fading of immunofluorescence during microscopy
Johnson, G. D., & de C. Nogueira Araujo, G. M. (1981) · Journal of Immunological Methods · doi:10.1016/0022-1759(81)90183-6 · Cited by 1,863
D'Ercole, A. J., Stiles, A. D., & Underwood, L. E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.3.935 · Cited by 1,186
Somatomedin: Proposed Designation for Sulphation Factor
DAUGHADAY, W. H., HALL, K., RABEN, M. S., SALMON, W. D., LEO VAN DEN BRANDE, J., & VAN WYK, J. J. (1972) · Nature · doi:10.1038/235107a0 · Cited by 842
Insulin-like growth factor I stimulates growth in hypophysectomized rats
Schoenle, E., Zapf, J., Humbel, R. E., & Froesch, E. R. (1982) · Nature · doi:10.1038/296252a0 · Cited by 596
Growth Hormone Stimulates Longitudinal Bone Growth Directly
Isaksson, O. G. P., Jansson, J.-O., & Gause, I. A. M. (1982) · Science · doi:10.1126/science.7079756 · Cited by 525
Self-citationHormonal Control of Immunoreactive Somatomedin Production by Cultured Human Fibroblasts
Clemmons, D. R., Underwood, L. E., & Van Wyk, J. J. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110001 · Cited by 318
SEQUENCE ANALYSIS OF SOMATOMEDIN-C: CONFIRMATION OF IDENTITY WITH INSULIN-LIKE GROWTH FACTOR I
KLAPPER, D. G., SVOBODA, M. E., & VAN WYK, J. J. (1983) · Endocrinology · doi:10.1210/endo-112-6-2215 · Cited by 293
Growth hormone and the adipose conversion of 3T3 cells
Morikawa, M., Nixon, T., & Green, H. (1982) · Cell · doi:10.1016/0092-8674(82)90440-8 · Cited by 256
Cited by
Role of insulin-like growth factors in embryonic and postnatal growth
Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463
The Somatomedin Hypothesis: 2001
Le Roith, D., Bondy, C., Yakar, S., Liu, J.-L., & Butler, A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0419 · Cited by 1,257
Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth
Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A., & Leder, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81069-7 · Cited by 1,070
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
Roles of Growth Hormone and Insulin-like Growth Factor 1 in Mouse Postnatal Growth
Lupu, F., Terwilliger, J. D., Lee, K., Segre, G. V., & Efstratiadis, A. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9975 · Cited by 771
Metadata
- Authors
- Nilsson, A., Isgaard, J., Lindahl, A., Dahlström, A., Skottner, A., & Isaksson, O. G. P.
- Venue
- Science
- Published
- 1986-08
- Volume
- 233
- Issue
- 4763
- Pages
- 571-574
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052764940
- Cited by
- 318
- References
- 16
- FWCI
- 17.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Regulation by Growth Hormone of Number of Chondrocytes Containing IGF-I in Rat Growth Plate. https://app.cochat.ai/papers/10.1126/science.3523759
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- Nilsson, A., Isgaard, J., Lindahl, A., Dahlström, A., Skottner, A., & Isaksson, O. G. P. (1986). Regulation by Growth Hormone of Number of Chondrocytes Containing IGF-I in Rat Growth Plate. Science. https://doi.org/10.1126/science.3523759
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
