Role of insulin-like growth factors in embryonic and postnatal growth
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A developmental analysis of growth kinetics in mouse embryos carrying null mutations of the genes encoding insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor (IGF1R), alone or in combination, defined the onset of mutational effects leading to growth deficiency and indicated that between embryonic days 11.0 and 12.5, IGF1R serves only the in vivo mitogenic signaling of IGF-II. From E13.5 onward, IGF1R interacts with both IGF-I and IGF-II, while IGF-II recognizes an additional unknown receptor (XR). In contrast with the embryo proper, placental growth is served exclusively by an IGF-II-XR interaction. Additional genetic data suggested that the type 2IGF/mannose 6-phosphate receptor is an unlikely candidate for XR. Postnatal growth curves indicated that surviving Igf-1(-/-) mutants, which are infertile and exhibit delayed bone development, continue to grow with a retarded rate after birth in comparison with wild-type littermates and become 30% of normal weight as adults.
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IGF2 functions predominantly in early embryogenesis.
“While IGF2 functions predominantly in early embryogenesis [226]”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [226]
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- Authors
- Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A.
- Affiliations
- Columbia University (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-10
- Volume
- 75
- Issue
- 1
- Pages
- 73-82
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2017949036
- Cited by
- 2,463
- References
- 82
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 58 · 2023: 41 · 2022: 53 · 2021: 52 · 2020: 75 · 2019: 41 · 2018: 61 · 2017: 55 · 2016: 61 · 2015: 60 · 2014: 77 · 2013: 101 · 2012: 95
- FWCI
- 55.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Raymond and Beverly Sackler Foundation
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- insulin-like growth factor I, insulin-like growth factor II, IGF-1 receptor, IGF-II receptor, embryo growth, postnatal growth, growth deficiency, placental development, mitogenic signaling, mouse mutants, growth kinetics
- MeSH terms
- Aging, Animals, Female, Embryonic and Fetal Development, Fetus, Gestational Age, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Mice, Mutant Strains, Placenta, Pregnancy, Point Mutation, Receptor, IGF Type 1, Mice
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