Cited by 2,463Growth Hormone and Insulin-like Growth FactorsGenetic Syndromes and ImprintingBirth, Development, and Health

Role of insulin-like growth factors in embryonic and postnatal growth

Open access
Baker, Julie, Liu, Jeh-Ping, Robertson, Elizabeth J., Efstratiadis, Argiris·1993·Cell

Abstract

A developmental analysis of growth kinetics in mouse embryos carrying null mutations of the genes encoding insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor (IGF1R), alone or in combination, defined the onset of mutational effects leading to growth deficiency and indicated that between embryonic days 11.0 and 12.5, IGF1R serves only the in vivo mitogenic signaling of IGF-II. From E13.5 onward, IGF1R interacts with both IGF-I and IGF-II, while IGF-II recognizes an additional unknown receptor (XR). In contrast with the embryo proper, placental growth is served exclusively by an IGF-II-XR interaction. Additional genetic data suggested that the type 2IGF/mannose 6-phosphate receptor is an unlikely candidate for XR. Postnatal growth curves indicated that surviving Igf-1(-/-) mutants, which are infertile and exhibit delayed bone development, continue to grow with a retarded rate after birth in comparison with wild-type littermates and become 30% of normal weight as adults.

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Crossref · 10.1016/s0092-8674(05)80085-6

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Authors
Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A.
Affiliations
Columbia University (US)
Venue
Cell
Publisher
Elsevier BV
Published
1993-10
Volume
75
Issue
1
Pages
73-82
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2017949036
Cited by
2,463
References
82
Citations by year
2026: 17 · 2025: 26 · 2024: 58 · 2023: 41 · 2022: 53 · 2021: 52 · 2020: 75 · 2019: 41 · 2018: 61 · 2017: 55 · 2016: 61 · 2015: 60 · 2014: 77 · 2013: 101 · 2012: 95
FWCI
55.66
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • Cell (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Raymond and Beverly Sackler Foundation
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
insulin-like growth factor I, insulin-like growth factor II, IGF-1 receptor, IGF-II receptor, embryo growth, postnatal growth, growth deficiency, placental development, mitogenic signaling, mouse mutants, growth kinetics
MeSH terms
Aging, Animals, Female, Embryonic and Fetal Development, Fetus, Gestational Age, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Mice, Mutant Strains, Placenta, Pregnancy, Point Mutation, Receptor, IGF Type 1, Mice

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