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Cited by 901

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Splicing of Messenger RNA Precursors

Sharp, Phillip A.·1987·Science

Abstract

A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns. The splicing of nuclear messenger RNA precursors involves the formation of a multicomponent complex, the spliceosome. This splicing body contains at least three different small nuclear ribonucleoprotein particles (snRNPs), U2, U5, and U4 + U6. A complex containing precursor RNA and the U2 snRNP particle is a likely intermediate in the formation of the spliceosome.

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Metadata

Authors
Sharp, P. A.
Venue
Science
Published
1987-02-13
Volume
235
Issue
4790
Pages
766-771
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2173963963
Cited by
901
References
1
FWCI
52.44
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Splicing of Messenger RNA Precursors. https://app.cochat.ai/papers/10.1126/science.3544217
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Sharp, P. A. (1987). Splicing of Messenger RNA Precursors. Science. https://doi.org/10.1126/science.3544217

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.