RNA evolution and the origins of life
Abstract
The evolution of RNA is likely to have played an important role in the very early history of life on Earth but it is doubtful that life began with RNA. Consideration of what came before RNA must take into account relevant information from geochemistry, prebiotic chemistry and nucleic acid biochemistry.
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The RNA World hypothesis holds that an early phase of life, prior to coded protein synthesis, had cellular biochemistry and genetics largely carried out by RNA.
“Considerable evidence supports the RNA World hypothesis of an early phase of life, prior to the evolution of coded protein synthesis, in which cellular biochemistry and genetics were largely the province of RNA (reviewed in [1,2]).”
From The eightfold path to non-enzymatic RNA replication (2012) · cites this paper as [1]
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Sowerby, S. J., Holm, N. G., & Petersen, G. B. (2001) · Biosystems · doi:10.1016/s0303-2647(01)00130-7 · Cited by 34 · see citing works
Prebiotic co-evolution of self-replication and translation or RNA world?
Lahav, N. (1991) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(05)80368-6 · Cited by 28 · see citing works
The basic reproductive ratio of life
Manapat, M. L., Chen, I. A., & Nowak, M. A. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.12.020 · Cited by 19 · see citing works
Manapat, M., Ohtsuki, H., Bürger, R., & Nowak, M. A. (2009) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.10.006 · Cited by 12 · see citing works
- Authors
- Joyce, G. F.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Joyce, Gerald F.
- ORCID
- Joyce, Gerald F.
- Venue
- Nature
- Published
- 1989-03
- Volume
- 338
- Issue
- 6212
- Pages
- 217-224
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1976379862
- Cited by
- 658
- References
- 84
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 16 · 2023: 19 · 2022: 24 · 2021: 18 · 2020: 9 · 2019: 20 · 2018: 9 · 2017: 17 · 2016: 13 · 2015: 16 · 2014: 12 · 2013: 20 · 2012: 18
- FWCI
- 47.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- RNA evolution, origin of life, prebiotic chemistry, nucleic acid biochemistry, geochemistry, early Earth
- MeSH terms
- Origin of Life, Carbohydrates, Biological Evolution, Models, Molecular, Purines, RNA
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