The DOI matches its Crossref record.
Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil
Abstract
The parasite Plasmodium falciparum , like neoplastic cells, develops resistance to multiple structurally unrelated drugs. If the mechanisms by which P. falciparum and neoplastic cells become resistant are similar, then it may be possible to reverse the resistance in the two types of cells by the same pharmacological agents. Verapamil, a calcium channel blocker, completely reversed chloroquine resistance in two chloroquine-resistant P. falciparum clones from Southeast Asia and Brazil. Verapamil reversed chloroquine resistance at the same concentration (1 × 10 -6 M ) as that at which it reversed resistance in multidrug-resistant cultured neoplastic cells. This same concentration of verapamil had no effect on chloroquine-sensitive parasites. Hence, chloroquine resistance in P. falciparum may fit the criteria for the multidrug-resistant phenotype.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Fidock, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00084-8 · Cited by 1,456
Li, W., Zhang, H., Assaraf, Y. G., Zhao, K., Xu, X., Xie, J., Yang, D.-H., & Chen, Z.-S. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.05.001 · Cited by 673
Antimicrobial activity of psychotropic drugs
Munoz-Bellido, J. L., Munoz-Criado, S., & Garcı̀a-Rodrı̀guez, J. A. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(99)00154-5 · Cited by 249
Recent advances in antimalarial drug development
Vangapandu, S., Jain, M., Kaur, K., Patil, P., Patel, S. R., & Jain, R. (2007) · Medicinal Research Reviews · doi:10.1002/med.20062 · Cited by 108
Intermittent preventive treatment of malaria in pregnancy: at the crossroads of public health policy
Chico, R. M., & Chandramohan, D. (2011) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2011.02765.x · Cited by 38
Metadata
- Authors
- Martin, S. K., Oduola, A. M. J., & Milhous, W. K.
- Venue
- Science
- Published
- 1987-02-20
- Volume
- 235
- Issue
- 4791
- Pages
- 899-901
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984979458
- Cited by
- 579
- References
- 0
- FWCI
- 36.49
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil. https://app.cochat.ai/papers/10.1126/science.3544220
- The paper
- Martin, S. K., Oduola, A. M. J., & Milhous, W. K. (1987). Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil. Science. https://doi.org/10.1126/science.3544220
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
