The DOI matches its Crossref record, with a small difference in title or year; 15 of the 15 references it cites were found in a registry or an index.
Antimicrobial activity of psychotropic drugs
Abstract
Psychotropic drugs have been shown to have antimicrobial activity against several groups of microorganisms. Some of these drugs, such as the new antidepressant agents sertraline, fluoxetine and paroxetine are known to act as efflux pump inhibitors in human cells. Their activity has been studied, alone and combined with antibiotics, against bacterial species, mainly in multiply resistant strains. These agents have surprising activity, mainly against Gram positive microorganisms. They also show synergistic activity when combined with some antibiotics against several bacteria, shown by a decrease in MICs, that converts strains previously resistant to the category of sensitive, and modify physiological aspects related with pathogenicity.
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The action of antidepressants and neuroleptics in microbes involves different biological processes, and several different components could be the target of these drugs.
“As reported in several works, the action of antidepressants and neuroleptics in microbes involves different biological processes, and it is suggested that several different components could be the target of these drugs [61].”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [61]
Antidepressants are well known to have antimicrobial effects, modulating the pathophysiology of anxiety and depression by reshaping not only brain biochemistry, but also the gut microbiota.
“Antidepressants are well known to have antimicrobial effects, modulating the pathophysiology of the anxiety and depression by reshaping not only brain biochemistry, but also the gut microbiota [159,160].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [160]
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Metadata
- Authors
- Munoz-Bellido, J. L., Munoz-Criado, S., & Garcı̀a-Rodrı̀guez, J. A.
- Venue
- International Journal of Antimicrobial Agents
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 14
- Issue
- 3
- Pages
- 177-180
- ISSN
- 0924-8579 (ISSN-L)
- OpenAlex
- W2050731629
- Cited by
- 249
- References
- 15
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 15 · 2023: 14 · 2022: 18 · 2021: 23 · 2020: 35 · 2019: 17 · 2018: 18 · 2017: 14 · 2016: 8 · 2015: 7 · 2014: 6 · 2013: 4 · 2012: 10
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Antimicrobial Agents (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- psychotropic drugs, antimicrobial activity, antidepressants, sertraline, fluoxetine, paroxetine, efflux pump inhibitors, antibiotic synergy, multidrug-resistant bacteria, Gram-positive bacteria, minimum inhibitory concentration, bacterial pathogenicity
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Corynebacterium, Drug Synergism, Fluoxetine, Gram-Positive Bacteria, Humans, Microbial Sensitivity Tests, Selective Serotonin Reuptake Inhibitors, Paroxetine, Sertraline
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