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Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia
Abstract
Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44 degrees C to that at 37 degrees C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection.
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Cited by
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Progress and challenges towards targeted delivery of cancer therapeutics
Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03705-y · Cited by 2,220
The Smart Drug Delivery System and Its Clinical Potential
Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066
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Metadata
- Authors
- Yatvin, M. B., Weinstein, J. N., Dennis, W. H., & Blumenthal, R.
- Venue
- Science
- Published
- 1978-12-22
- Volume
- 202
- Issue
- 4374
- Pages
- 1290-1293
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1998886157
- Cited by
- 956
- References
- 0
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yatvin, M. B., Weinstein, J. N., Dennis, W. H., & Blumenthal, R. (1978). Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia. Science. https://doi.org/10.1126/science.364652
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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