The DOI matches its Crossref record.
Reduction to Homozygosity of Genes on Chromosome 11 in Human Breast Neoplasia
Abstract
The somatic loss of heterozygosity for normal alleles occurring in human tumors has suggested the presence of recessive oncogenes. The results presented here demonstrate a loss of heterozygosity of several genes on chromosome 11 in primary breast tumors. Restriction fragment length polymorphism analysis of these DNAs further suggests that the most frequent loss of sequences in breast tumors occurs between the β-globin and parathyroid hormone loci on the short arm of chromosome 11. The loss of heterozygosity for chromosome 11 loci has a significant association with tumors that lack estrogen and progesterone receptors, grade III tumors, and distal metastasis.
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Cited by
Roodman, G. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030831 · Cited by 2,755
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Veronese, A., Lupini, L., Consiglio, J., Visone, R., Ferracin, M., Fornari, F., Zanesi, N., Alder, H., D'Elia, G., Gramantieri, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4456 · Cited by 210
Metadata
- Authors
- Ali, I. U., Lidereau, R., Theillet, C., & Callahan, R.
- Venue
- Science
- Published
- 1987-10-09
- Volume
- 238
- Issue
- 4824
- Pages
- 185-188
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037749822
- Cited by
- 324
- References
- 0
- FWCI
- 27.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reduction to Homozygosity of Genes on Chromosome 11 in Human Breast Neoplasia. https://app.cochat.ai/papers/10.1126/science.3659909
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- Ali, I. U., Lidereau, R., Theillet, C., & Callahan, R. (1987). Reduction to Homozygosity of Genes on Chromosome 11 in Human Breast Neoplasia. Science. https://doi.org/10.1126/science.3659909
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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