The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Parathyroid Hormone-Related Protein of Malignancy: Active Synthetic Fragments
Abstract
Peptides corresponding to the amino-terminal region of the parathyroid hormone-related protein (PTHrP) of humoral hypercalcemia of malignancy were synthesized. A 34-amino acid peptide, PTHrP(1-34), was two to four times more potent than bovine or human PTH(1-34) in bioassays promoting the formation of adenosine 3′,5′-monophosphate (cAMP) and plasminogen activator activity in osteogenic sarcoma cells and adenylate cyclase activity in chick kidney membranes. Like parathyroid hormone itself, in which the activity resides in the first 34 residues, PTHrP peptides of less than 30 residues from the amino terminus showed substantially reduced activity. PTHrP(1-34) had only 6% of the potency of bovine PTH(1-34) in promoting bone resorption in vitro. PTHrP(1-34) strongly promoted the excretion of cAMP and phosphorus and reduced the excretion of calcium in the isolated, perfused rat kidney consistent with the symptoms seen in malignant hypercalcemia.
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Citations
Cites
Role of osteoblasts in hormonal control of bone resorption—A hypothesis
Rodan, G. A., & Martin, T. J. (1981) · Calcified Tissue International · doi:10.1007/bf02409454 · Cited by 982
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Cited by
Seymour, J., & Gagel, R. (1993) · Blood · doi:10.1182/blood.v82.5.1383.1383 · Cited by 291
Mak, K. K., Bi, Y., Wan, C., Chuang, P.-T., Clemens, T., Young, M., & Yang, Y. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.02.003 · Cited by 202
Chorev, M., Roubini, E., McKee, R. L., Gibbons, S. W., Goldman, M. E., Caulfield, M. P., & Rosenblatt, M. (1991) · Biochemistry · doi:10.1021/bi00238a022 · Cited by 107
Metadata
- Authors
- Kemp, B. E., Moseley, J. M., Rodda, C. P., Ebeling, P. R., Wettenhall, R. E. H., Stapleton, D., Diefenbach-Jagger, H., Ure, F., Michelangeli, V. P., Simmons, H. A., Raisz, L. G., & Martin, T. J.
- Venue
- Science
- Published
- 1987-12-11
- Volume
- 238
- Issue
- 4833
- Pages
- 1568-1570
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062731377
- Cited by
- 373
- References
- 1
- FWCI
- 43.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kemp, B. E., Moseley, J. M., Rodda, C. P., Ebeling, P. R., Wettenhall, R. E. H., Stapleton, D., Diefenbach-Jagger, H., Ure, F., Michelangeli, V. P., Simmons, H. A., Raisz, L. G., & Martin, T. J. (1987). Parathyroid Hormone-Related Protein of Malignancy: Active Synthetic Fragments. Science. https://doi.org/10.1126/science.3685995
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
