The DOI matches its Crossref record.
Three-Dimensional Structure of the Adenovirus Major Coat Protein Hexon
Abstract
The three-dimensional crystal structure of the adenovirus major coat protein is presented. Adenovirus type 2 hexon, at 967 residues, is now the longest polypeptide whose structure has been determined crystallographically. Taken with our model for hexon packing, which positions the 240 trimeric hexons in the capsid, the structure defines 60% of the protein within the 150 × 10 6 dalton virion. The assembly provides the first details of a DNA-containing animal virus that is 20 times larger than the spherical RNA viruses previously described. Unexpectedly, the hexon subunit contains two similar β-barrels whose topology is identical to those of the spherical RNA viruses, but whose architectural role in adenovirus is very different. The hexon structure reveals several distinctive features related to its function as a stable protective coat, and shows that the type-specific immunological determinants are restricted to the virion surface.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Eck, M. J., & Sprang, S. R. (1990) · PubMed · doi:10.2210/pdb1tnf/pdb · Cited by 507
The three-dimensional structure of the bacterial virus MS2
Valegård, K., Liljas, L., Fridborg, K., & Unge, T. (1990) · Nature · doi:10.1038/345036a0 · Cited by 411
Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks
Liu, H., Jin, L., Koh, S. B. S., Atanasov, I., Schein, S., Wu, L., & Zhou, Z. H. (2010) · Science · doi:10.1126/science.1187433 · Cited by 384
Stewart, P. L., Fuller, S. D., & Burnett, R. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05919.x · Cited by 381
Self-citationThe Atomic Structure of Mengo Virus at 3.0 Å Resolution
Luo, M., Vriend, G., Kamer, G., Minor, I., Arnold, E., Rossmann, M. G., Boege, U., Scraba, D. G., Duke, G. M., & Palmenberg, A. C. (1987) · Science · doi:10.1126/science.3026048 · Cited by 357
Metadata
- Authors
- Roberts, M. M., White, J. L., Grütter, M. G., & Burnett, R. M.
- Venue
- Science
- Published
- 1986-05-30
- Volume
- 232
- Issue
- 4754
- Pages
- 1148-1151
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975725195
- Cited by
- 247
- References
- 0
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Three-Dimensional Structure of the Adenovirus Major Coat Protein Hexon. https://app.cochat.ai/papers/10.1126/science.3704642
- The paper
- Roberts, M. M., White, J. L., Grütter, M. G., & Burnett, R. M. (1986). Three-Dimensional Structure of the Adenovirus Major Coat Protein Hexon. Science. https://doi.org/10.1126/science.3704642
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
