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A Protein Induced During Nerve Growth (GAP-43) is a Major Component of Growth-Cone Membranes
Abstract
Growth cones are specialized structures that form the distal tips of growing axons. During both normal development of the nervous system and regeneration of injured nerves, growth cones are essential for elongation and guidance of growing axons. Developmental and regenerative axon growth is frequently accompanied by elevated synthesis of a protein designated GAP-43. GAP-43 has now been found to be a major component of growth-cone membranes in developing rat brains. Relative to total protein, GAP-43 is approximately 12 times as abundant in growth-cone membranes as in synaptic membranes from adult brains. Immunohistochemical localization of GAP-43 in frozen sections of developing brain indicates that the protein is specifically associated with neuropil areas containing growth cones and immature synaptic terminals. The results support the proposal that GAP-43 plays a role in axon growth.
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Citations
Cited by
Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones
Goslin, K., Schreyer, D. J., Skene, J. H. P., & Banker, G. (1988) · Nature · doi:10.1038/336672a0 · Cited by 417
Self-citationAnatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain
Benowitz, L., Apostolides, P., Perrone-Bizzozero, N., Finklestein, S., & Zwiers, H. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-01-00339.1988 · Cited by 386
Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth
Basi, G. S., Jacobson, R. D., Virág, I., Schilling, J., & Skene, J. H. P. (1987) · Cell · doi:10.1016/0092-8674(87)90616-7 · Cited by 355
Self-citationQi, Y., Wang, J. K. T., McMillian, M., & Chikaraishi, D. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-04-01217.1997 · Cited by 330
Markers of axonal injury in post mortem human brain
Sherriff, F. E., Bridges, L. R., Gentleman, S. M., Sivaloganathan, S., & Wilson, S. (1994) · Acta Neuropathologica · doi:10.1007/bf00389495 · Cited by 233
Metadata
- Authors
- Skene, J. H. P., Jacobson, R. D., Snipes, G. J., McGuire, C. B., Norden, J. J., & Freeman, J. A.
- Venue
- Science
- Published
- 1986-08-15
- Volume
- 233
- Issue
- 4765
- Pages
- 783-786
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057217877
- Cited by
- 512
- References
- 0
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Skene, J. H. P., Jacobson, R. D., Snipes, G. J., McGuire, C. B., Norden, J. J., & Freeman, J. A. (1986). A Protein Induced During Nerve Growth (GAP-43) is a Major Component of Growth-Cone Membranes. Science. https://doi.org/10.1126/science.3738509
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
