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Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription
Abstract
Cholinergic agonists rapidly and transiently induced transcription of the c- fos protooncogene and one or more actin genes in neuronally differentiated PC12 cells. Transcription was activated within minutes after stimulation of the nicotinic acetylcholine receptor and required an influx of extracellular Ca 2+ ions through voltage-sensitive calcium channels. Nicotine activation proceeded by a different pathway from activation by nerve growth factor, whose stimulation of these genes is independent of extracellular Ca 2+ ions. These findings suggest that neurotransmitters may rapidly activate specific gene transcription in nondividing neuronally differentiated cells. They also suggest a functional role for neurotransmitter induction of c- fos and actin expression in the nervous system.
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Citations
Cited by
Llinás, R. R. (1988) · Science · doi:10.1126/science.3059497 · Cited by 2,285
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level
Sagar, S. M., Sharp, F. R., & Curran, T. (1988) · Science · doi:10.1126/science.3131879 · Cited by 1,925
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848
Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region
Moffitt, J. R., Bambah-Mukku, D., Eichhorn, S. W., Vaughn, E., Shekhar, K., Perez, J. D., Rubinstein, N. D., Hao, J., Regev, A., Dulac, C., et al. (2018) · Science · doi:10.1126/science.aau5324 · Cited by 1,365
Metadata
- Authors
- Greenberg, M. E., Ziff, E. B., & Greene, L. A.
- Venue
- Science
- Published
- 1986-10-03
- Volume
- 234
- Issue
- 4772
- Pages
- 80-83
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016773845
- Cited by
- 755
- References
- 0
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Greenberg, M. E., Ziff, E. B., & Greene, L. A. (1986). Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription. Science. https://doi.org/10.1126/science.3749894
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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