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Human Lipoprotein Lipase Complementary DNA Sequence
Abstract
Lipoprotein lipase is a key enzyme of lipid metabolism that acts to hydrolyze triglycerides, providing free fatty acids for cells and affecting the maturation of circulating lipoproteins. It has been proposed that the enzyme plays a role in the development of obesity and atherosclerosis. The human enzyme has been difficult to purify and its protein sequence was heretofore undetermined. A complementary DNA for human lipoprotein lipase that codes for a mature protein of 448 amino acids has now been cloned and sequenced. Analysis of the sequence indicates that human lipoprotein lipase, hepatic lipase, and pancreatic lipase are members of a gene family. Two distinct species of lipoprotein lipase messenger RNA that arise from alternative sites of 3′-terminal polyadenylation were detected in several different tissues.
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Citations
Cited by
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 741
Sugawara, T., Holt, J. A., Driscoll, D., Strauss, J. F., Lin, D., Miller, W. L., Patterson, D., Clancy, K. P., Hart, I. M., & Clark, B. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4778 · Cited by 382
Wong, H., & Schotz, M. C. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200007-jlr200 · Cited by 298
Self-citationWeinstock, P. H., Bisgaier, C. L., Aalto-Setälä, K., Radner, H., Ramakrishnan, R., Levak-Frank, S., Essenburg, A. D., Zechner, R., & Breslow, J. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118319 · Cited by 254
Metadata
- Authors
- Wion, K. L., Kirchgessner, T. G., Lusis, A. J., Schotz, M. C., & Lawn, R. M.
- Venue
- Science
- Published
- 1987-03-27
- Volume
- 235
- Issue
- 4796
- Pages
- 1638-1641
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969299547
- Cited by
- 479
- References
- 0
- FWCI
- 36.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wion, K. L., Kirchgessner, T. G., Lusis, A. J., Schotz, M. C., & Lawn, R. M. (1987). Human Lipoprotein Lipase Complementary DNA Sequence. Science. https://doi.org/10.1126/science.3823907
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
