The DOI matches its Crossref record.
Human Lipoprotein Lipase Complementary DNA Sequence
Abstract
Lipoprotein lipase is a key enzyme of lipid metabolism that acts to hydrolyze triglycerides, providing free fatty acids for cells and affecting the maturation of circulating lipoproteins. It has been proposed that the enzyme plays a role in the development of obesity and atherosclerosis. The human enzyme has been difficult to purify and its protein sequence was heretofore undetermined. A complementary DNA for human lipoprotein lipase that codes for a mature protein of 448 amino acids has now been cloned and sequenced. Analysis of the sequence indicates that human lipoprotein lipase, hepatic lipase, and pancreatic lipase are members of a gene family. Two distinct species of lipoprotein lipase messenger RNA that arise from alternative sites of 3′-terminal polyadenylation were detected in several different tissues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 741
Sugawara, T., Holt, J. A., Driscoll, D., Strauss, J. F., Lin, D., Miller, W. L., Patterson, D., Clancy, K. P., Hart, I. M., & Clark, B. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4778 · Cited by 382
Wong, H., & Schotz, M. C. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200007-jlr200 · Cited by 298
Self-citationWeinstock, P. H., Bisgaier, C. L., Aalto-Setälä, K., Radner, H., Ramakrishnan, R., Levak-Frank, S., Essenburg, A. D., Zechner, R., & Breslow, J. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118319 · Cited by 254
Human digestive and metabolic lipases—A brief review
Mukherjee, M. (2003) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/s1381-1177(03)00052-3 · Cited by 217
Semenkovich, C. F., Chen, S. H., Wims, M., Luo, C. C., Li, W. H., & Chan, L. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38369-3 · Cited by 160
Chappell, D. A., Fry, G. L., Waknitz, M. A., Iverius, P. H., Williams, S. E., & Strickland, D. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35675-8 · Cited by 133
Lipoprotein lipase: From gene to atherosclerosis
Li, Y., He, P.-P., Zhang, D.-W., Zheng, X.-L., Cayabyab, F. S., Yin, W.-D., & Tang, C.-K. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.016 · Cited by 109
Genetic Mutations Affecting Human Lipoproteins, Their Receptors, and Their Enzymes
Zannis, V. I., Kardassis, D., & Zanni, E. E. (1993) · Advances in Human Genetics 21 · doi:10.1007/978-1-4615-3010-7_3 · Cited by 78
Localization of lipoprotein lipase mRNA in selected rat tissues
Goldberg, I. J., Soprano, D. R., Wyatt, M. L., Vanni, T. M., Kirchgessner, T. G., & Schotz, M. C. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38241-9 · Cited by 77
Self-citationReina, M., Brunzell, J., & Deeb, S. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41340-9 · Cited by 74
Patalay, M., Lofgren, I. E., Freake, H. C., Koo, S. I., & Fernandez, M. L. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.4.735 · Cited by 53
Metadata
- Authors
- Wion, K. L., Kirchgessner, T. G., Lusis, A. J., Schotz, M. C., & Lawn, R. M.
- Venue
- Science
- Published
- 1987-03-27
- Volume
- 235
- Issue
- 4796
- Pages
- 1638-1641
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969299547
- Cited by
- 479
- References
- 0
- FWCI
- 36.62
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
