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Lipoprotein lipase: From gene to atherosclerosis

Li, Yuan, He, Ping-Ping, Zhang, Da-Wei, Zheng, Xi-Long, Cayabyab, Fracisco S., Yin, Wei-Dong, Tang, Chao-Ke·2014·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2014.10.016
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Abstract

Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and responsible for catalyzing lipolysis of triglycerides in lipoproteins. LPL is produced mainly in adipose tissue, skeletal and heart muscle, as well as in macrophage and other tissues. After synthesized, it is secreted and translocated to the vascular lumen. LPL expression and activity are regulated by a variety of factors, such as transcription factors, interactive proteins and nutritional state through complicated mechanisms. LPL with different distributions may exert distinct functions and have diverse roles in human health and disease with close association with atherosclerosis. It may pose a pro-atherogenic or an anti-atherogenic effect depending on its locations. In this review, we will discuss its gene, protein, synthesis, transportation and biological functions, and then focus on its regulation and relationship with atherosclerosis and potential underlying mechanisms. The goal of this review is to provide basic information and novel insight for further studies and therapeutic targets.

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Metadata

Authors
Li, Y., He, P.-P., Zhang, D.-W., Zheng, X.-L., Cayabyab, F. S., Yin, W.-D., & Tang, C.-K.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2014-12
Volume
237
Issue
2
Pages
597-608
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2014.10.016
Cited by
109
References
12
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Natural Science Foundation of China (81270269, 81170278, 81370377, 81300158, 81300224)
  • Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, China (2008-244)

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