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Control of Cytochrome P 1 -450 Gene Expression by Dioxin
Abstract
The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) may produce its effects by altering gene expression in susceptible cells. In mouse hepatoma cells, TCDD induces the transcription of the cytochrome P 1 -450 gene, whose product, aryl hydrocarbon hydroxylase, contributes both to the detoxification and to the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons. A DNA fragment containing sequences flanking the 5′ end of the cytochrome P 1 -450 gene was isolated and analyzed. This DNA fragment contains a cis-acting control element with at least three functional domains: a putative promoter, an inhibitory domain upstream from the promoter that blocks its function, and a TCDD-responsive domain still farther (1265 to 1535 base pairs) upstream of the promoter. These findings, together with results from earlier studies, imply that transcription of the cytochrome P 1 -450 gene is under both positive and negative control by at least two trans -acting regulatory factors.
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Cited by
Safe, S. (1990) · Critical Reviews in Toxicology · doi:10.3109/10408449009089873 · Cited by 1,871
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727
Apetoh, L., Quintana, F. J., Pot, C., Joller, N., Xiao, S., Kumar, D., Burns, E. J., Sherr, D. H., Weiner, H. L., & Kuchroo, V. K. (2010) · Nature Immunology · doi:10.1038/ni.1912 · Cited by 725
Safe, S. H. (1986) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.26.040186.002103 · Cited by 710
Denison, M. S., Fisher, J. M., & Whitlock, J. P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77819-3 · Cited by 451
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Metadata
- Authors
- Jones, P. B. C., Galeazzi, D. R., Fisher, J. M., & Whitlock, J. P.
- Venue
- Science
- Published
- 1985-03-22
- Volume
- 227
- Issue
- 4693
- Pages
- 1499-1502
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065279356
- Cited by
- 266
- References
- 0
- FWCI
- 49.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jones, P. B. C., Galeazzi, D. R., Fisher, J. M., & Whitlock, J. P. (1985). Control of Cytochrome P 1 -450 Gene Expression by Dioxin. Science. https://doi.org/10.1126/science.3856321
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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