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Cited by 725T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

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Apetoh, Lionel, Quintana, Francisco J, Pot, Caroline, Joller, Nicole, Xiao, Sheng, Kumar, Deepak, Burns, Evan J, Sherr, David H +2 more·2010·Nature Immunology
DOI 10.1038/ni.1912PMC PMC2940320
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Abstract

Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are instrumental in the prevention of tissue inflammation, autoimmunity and graft-versus-host disease. The transcription factor c-Maf is essential for the induction of IL-10 by Tr1 cells, but the molecular mechanisms that lead to the development of these cells remain unclear. Here we show that the ligand-activated transcription factor aryl hydrocarbon receptor (AhR), which was induced by IL-27, acted in synergy with c-Maf to promote the development of Tr1 cells. After T cell activation under Tr1-skewing conditions, the AhR bound to c-Maf and promoted transactivation of the Il10 and Il21 promoters, which resulted in the generation of Tr1 cells and the amelioration of experimental autoimmune encephalomyelitis. Manipulating AhR signaling could therefore be beneficial in the resolution of excessive inflammatory responses.

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  • Previous studies have highlighted the neuroprotective roles of IL-36 and IL-27, and the inflammatory effects of IL-20RB and IL-11.

    “Previous studies have highlighted the neuroprotective roles of IL‐36 and IL‐27, and the inflammatory effects of IL‐20RB and IL‐11 (Dayton et al. 2021; Ng et al. 2020; Apetoh et al. 2010; Chen et al. 2022; Me et al. 2021).”

    From Transcript and Lipid Profile Alterations in Astrocyte‐Neuron Mitochondrial Transfer Under Lipopolysaccharide Exposure: An In Vitro Study (2025) · cites this paper as Apetoh et al. 2010

    The Results section (‘AhR controls the IL-27-mediated inhibition of EAE’) reports that IL-27 treatment of donor T cells reduced the incidence of experimental autoimmune encephalomyelitis, supporting a protective role in this CNS autoimmune disease model. Our copy does not address IL-36, IL-20RB, or IL-11, or establish neuroprotection beyond that model. (LLM, conf=0.85)

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Authors
Apetoh, L., Quintana, F. J., Pot, C., Joller, N., Xiao, S., Kumar, D., Burns, E. J., Sherr, D. H., Weiner, H. L., & Kuchroo, V. K.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
  • Boston University (US)
Corresponding author
  • Weiner, Howard L
  • Kuchroo, Vijay K
ORCID
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2010-08-01
Volume
11
Issue
9
Pages
854-861
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
DOI
10.1038/ni.1912
PMC
PMC2940320
OpenAlex
W2052006922
Cited by
725
References
1
Citations by year
2026: 17 · 2025: 38 · 2024: 28 · 2023: 40 · 2022: 47 · 2021: 50 · 2020: 51 · 2019: 39 · 2018: 52 · 2017: 60 · 2016: 47 · 2015: 47 · 2014: 53 · 2013: 50 · 2012: 45
FWCI
19.87
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (RG4111A1)
  • National Institute of Allergy and Infectious Diseases (R00AI075285, K99AI075285, R01AI093903, P01AI056299, R56AI093903, P01AI039671, AI435801)
  • National Institute of Neurological Disorders and Stroke (R01NS030843, NS 38037, P01NS038037, R37NS030843)
  • National Institute of Environmental Health Sciences (P01ES011624)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords
aryl hydrocarbon receptor, c-Maf, type 1 regulatory T cells, IL-27, IL-10, IL-21, T cell differentiation, transcriptional synergy, experimental autoimmune encephalomyelitis, autoinflammatory disease, inflammation resolution
MeSH terms
Animals, Cell Differentiation, Cells, Cultured, Gene Expression Regulation, Interleukins, Mice, Inbred C57BL, Receptors, Aryl Hydrocarbon, Cell Line, Tumor, T-Lymphocytes, Regulatory, Oncogene Protein v-maf, Mice

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