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Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization
Abstract
Human factor VIII—von Willebrand factor (vWF) is a large, multimeric glycoprotein that plays a central role in the blood coagulation system, serving both as a carrier for factor VIIIC (antihemophilic factor) and as a major mediator of platelet-vessel wall interaction. Diminished or abnormal vWF activity results in von Willebrand's disease (vWD), a common and complex hereditary bleeding disorder. Overlapping vWF cDNA clones that span 8.2 kilobases of the vWF messenger RNA have been obtained. vWF accounts for approximately 0.3 percent of endothelial cell messenger RNA and was undetectable in several other tissues examined. A large single copy gene for vWF is located on the short arm of chromosome 12 (12p12 → 12pter). No gross gene rearrangement or deletion was detected in the DNA of two patients with severe vWD.
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Citations
Cited by
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
Levy, G. G., Nichols, W. C., Lian, E. C., Foroud, T., McClintick, J. N., McGee, B. M., Yang, A. Y., Siemieniak, D. R., Stark, K. R., Gruppo, R., et al. (2001) · Nature · doi:10.1038/35097008 · Cited by 1,749
Self-citationBIOCHEMISTRY AND GENETICS OF VON WILLEBRAND FACTOR
Sadler, J. E. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.395 · Cited by 1,363
The molecular basis of blood coagulation
Furie, B., & Furie, B. C. (1988) · Cell · doi:10.1016/0092-8674(88)90567-3 · Cited by 1,247
The effect of ABO blood group on the diagnosis of von Willebrand disease
Gill, J., Endres-Brooks, J., Bauer, P., Marks, W. J., & Montgomery, R. (1987) · Blood · doi:10.1182/blood.v69.6.1691.1691 · Cited by 957
Royer-Pokora, B., Kunkel, L. M., Monaco, A. P., Goff, S. C., Newburger, P. E., Baehner, R. L., Cole, F. S., Curnutte, J. T., & Orkin, S. H. (1986) · Nature · doi:10.1038/322032a0 · Cited by 833
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Metadata
- Authors
- Ginsburg, D., Handin, R. I., Bonthron, D. T., Donlon, T. A., Bruns, G. A. P., Latt, S. A., & Orkin, S. H.
- Venue
- Science
- Published
- 1985-06-21
- Volume
- 228
- Issue
- 4706
- Pages
- 1401-1406
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076354748
- Cited by
- 432
- References
- 0
- FWCI
- 18.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization. https://app.cochat.ai/papers/10.1126/science.3874428
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- Ginsburg, D., Handin, R. I., Bonthron, D. T., Donlon, T. A., Bruns, G. A. P., Latt, S. A., & Orkin, S. H. (1985). Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization. Science. https://doi.org/10.1126/science.3874428
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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