The DOI matches its Crossref record.
Reductions in Arterial Diameter Produced by Chronic Decreases in Blood Flow Are Endothelium-Dependent
Abstract
A 70 percent reduction in the rate of blood flow through the common carotid artery in rabbits caused a 21 percent decrease in the diameter of this artery within 2 weeks. The smooth muscle relaxant papaverine did not attenuate the response; therefore, such reductions in diameter probably reflect a structural modification of the arterial wall rather than sustained contraction of smooth muscle. This arterial response to reduced blood flow was abolished when the endothelium was removed from the vessels. It appears that the endothelium is essential for the compensatory arterial response to long-term changes in luminal blood flow rates.
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Citations
Cited by
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Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Brown, G., Albers, J. J., Fisher, L. D., Schaefer, S. M., Lin, J.-T., Kaplan, C., Zhao, X.-Q., Bisson, B. D., Fitzpatrick, V. F., & Dodge, H. T. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011083231901 · Cited by 2,159
Effect of exercise training on endothelium‐derived nitric oxide function in humans
Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068197 · Cited by 1,040
Metadata
- Authors
- Langille, B. L., & O'Donnell, F.
- Venue
- Science
- Published
- 1986-01-24
- Volume
- 231
- Issue
- 4736
- Pages
- 405-407
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972789975
- Cited by
- 1,113
- References
- 0
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Langille, B. L., & O'Donnell, F. (1986). Reductions in Arterial Diameter Produced by Chronic Decreases in Blood Flow Are Endothelium-Dependent. Science. https://doi.org/10.1126/science.3941904
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
