The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Regulation of Erythrocyte Cation and Water Content in Sickle Cell Anemia
Abstract
The pathophysiological events in sickle cell disease are critically dependent on the intracellular concentration of hemoglobin S, which varies inversely with cell cation and water content. Erythrocytes of SS homozygotes exposed to oxygen or carbon monoxide decrease their potassium and water content through a pathway for potassium transport that is activated by both cell swelling and decrease in internal p H. This pathway is not inhibited by ouabain either with or without bumetanide. When SS erythrocytes were separated according to density, the p H- and volume-dependent potassium transport was greatest in the least dense fraction and was reduced in the densest cells. This pathway, which does not depend on polymerization of sickle hemoglobin, may be important in regulating the cation and water content of SS erythrocytes.
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Citations
Cites
Kinetics of sickle hemoglobin polymerization
Ferrone, F. A., Hofrichter, J., & Eaton, W. A. (1985) · Journal of Molecular Biology · doi:10.1016/0022-2836(85)90175-5 · Cited by 502
Kinetics of sickle hemoglobin polymerization
Ferrone, F. A., Hofrichter, J., & Eaton, W. A. (1985) · Journal of Molecular Biology · doi:10.1016/0022-2836(85)90174-3 · Cited by 288
Kaul, D. K., Fabry, M. E., Windisch, P., Baez, S., & Nagel, R. L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110960 · Cited by 225
Deformability of oxygenated irreversibly sickled cells.
Clark, M. R., Mohandas, N., & Shohet, S. B. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109650 · Cited by 177
Brugnara, C., Kopin, A. S., Bunn, H. F., & Tosteson, D. C. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111867 · Cited by 176
Self-citationEaton, W., Hofrichter, J., & Ross, P. (1976) · Blood · doi:10.1182/blood.v47.4.621.bloodjournal474621 · Cited by 167
THE EFFECTS OF SICKLING ON ION TRANSPORT
Tosteson, D. C., CARLSEN, E. N., & Dunham, E. T. (1955) · The Journal of General Physiology · doi:10.1085/jgp.39.1.31 · Cited by 153
Self-citationEaton, W., Hofrichter, J., & Ross, P. (1976) · Blood · doi:10.1182/blood.v47.4.621.621 · Cited by 126
Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles
Lew, V. L., Hockaday, A. R., Sepúlveda, M.-I., Somlyo, A. P., Somlyo, A. V., Ortiz, O. E., & Bookchin, R. M. (1985) · Nature · doi:10.1038/315586a0 · Cited by 117
POTASSIUM AND SODIUM OF RED BLOOD CELLS IN SICKLE CELL ANEMIA 1
Tosteson, D. C., Shea, E., & Darling, R. C. (1952) · Journal of Clinical Investigation · doi:10.1172/jci102623 · Cited by 113
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Cited by
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
Pathogenesis and Treatment of Sickle Cell Disease
Bunn, H. F. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709113371107 · Cited by 1,154
Self-citationSickle Cell Hemoglobin Polymerization
Eaton, W. A., & Hofrichter, J. (1990) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60287-9 · Cited by 623
Membrane Mechanisms and Intracellular Signalling in Cell Volume Regulation
(1995) · International Review of Cytology · doi:10.1016/s0074-7696(08)62498-5 · Cited by 469
Brugnara, C., de Franceschi, L., & Alper, S. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116597 · Cited by 360
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Metadata
- Authors
- Brugnara, C., Bunn, H. F., & Tosteson, D. C.
- Venue
- Science
- Published
- 1986-04-18
- Volume
- 232
- Issue
- 4748
- Pages
- 388-390
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039511387
- Cited by
- 261
- References
- 15
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brugnara, C., Bunn, H. F., & Tosteson, D. C. (1986). Regulation of Erythrocyte Cation and Water Content in Sickle Cell Anemia. Science. https://doi.org/10.1126/science.3961486
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
