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Evoked Mechanical Responses of Isolated Cochlear Outer Hair Cells
Abstract
Intracellular current administration evokes rapid, graded, and bidirectional mechanical responses of isolated outer hair cells from the mammalian inner ear. The cells become shorter in response to depolarizing and longer in response to hyperpolarizing currents in the synaptic end of the cell. The cells respond with either an increase or decrease in length to transcellular alternating current stimulation. The direction of the movement with transcellular stimuli appears to be frequency dependent. Iontophoretic application of acetylcholine to the synaptic end of the cell decreases its length. The microarchitecture of the organ of Corti permits length changes of outer hair cells in a manner that could significantly influence the mechanics of the cochlear partition and thereby contribute to the exquisite sensitivity of mammalian hearing.
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Citations
Cited by
Dallos, P. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04575.1992 · Cited by 710
Cochlear Outer Hair Cell Motility
Ashmore, J. (2008) · Physiological Reviews · doi:10.1152/physrev.00044.2006 · Cited by 503
The mechanisms and functions of synaptic facilitation.
Jackman, S. L., & Regehr, W. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.047 · Cited by 489
MECHANISMS OF HAIR CELL TUNING
Fettiplace, R., & Fuchs, P. A. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.809 · Cited by 417
Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification
Dallos, P., Wu, X., Cheatham, M. A., Gao, J., Zheng, J., Anderson, C. T., Jia, S., Wang, X., Cheng, W. H. Y., Sengupta, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.028 · Cited by 414
Metadata
- Authors
- Brownell, W. E., Bader, C. R., Bertrand, D., & de Ribaupierre, Y.
- Venue
- Science
- Published
- 1985-01-11
- Volume
- 227
- Issue
- 4683
- Pages
- 194-196
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074276238
- Cited by
- 1,826
- References
- 0
- FWCI
- 26.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brownell, W. E., Bader, C. R., Bertrand, D., & de Ribaupierre, Y. (1985). Evoked Mechanical Responses of Isolated Cochlear Outer Hair Cells. Science. https://doi.org/10.1126/science.3966153
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