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Evoked Mechanical Responses of Isolated Cochlear Outer Hair Cells

Brownell, William E., Bader, Charles R., Bertrand, Daniel, de Ribaupierre, Yves·1985·Science

Abstract

Intracellular current administration evokes rapid, graded, and bidirectional mechanical responses of isolated outer hair cells from the mammalian inner ear. The cells become shorter in response to depolarizing and longer in response to hyperpolarizing currents in the synaptic end of the cell. The cells respond with either an increase or decrease in length to transcellular alternating current stimulation. The direction of the movement with transcellular stimuli appears to be frequency dependent. Iontophoretic application of acetylcholine to the synaptic end of the cell decreases its length. The microarchitecture of the organ of Corti permits length changes of outer hair cells in a manner that could significantly influence the mechanics of the cochlear partition and thereby contribute to the exquisite sensitivity of mammalian hearing.

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Metadata

Authors
Brownell, W. E., Bader, C. R., Bertrand, D., & de Ribaupierre, Y.
Venue
Science
Published
1985-01-11
Volume
227
Issue
4683
Pages
194-196
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2074276238
Cited by
1,826
References
0
FWCI
26.22
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Evoked Mechanical Responses of Isolated Cochlear Outer Hair Cells. https://app.cochat.ai/papers/10.1126/science.3966153
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Brownell, W. E., Bader, C. R., Bertrand, D., & de Ribaupierre, Y. (1985). Evoked Mechanical Responses of Isolated Cochlear Outer Hair Cells. Science. https://doi.org/10.1126/science.3966153

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.