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Cited by 489Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

The mechanisms and functions of synaptic facilitation.

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Jackman, Skyler L., Regehr, Wade G.·2017·Neuron
DOI 10.1016/j.neuron.2017.02.047PMC PMC5865607
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Abstract

The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in information transfer and neural processing. Yet our understanding of the function of facilitation remains largely theoretical. Here we review proposed roles for facilitation and discuss how recent progress in uncovering the underlying molecular mechanisms could enable experiments that elucidate how facilitation, and short-term plasticity in general, contributes to circuit function and animal behavior.

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Crossref · 10.1016/j.neuron.2017.02.047

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  • There is currently a consensus that neurons and synapses constitute the fundamental electrochemical processing units of the human brain.

    “However, there is currently a consensus that neurons and synapses constitute the fundamental electrochemical processing units of the human brain”

    From Human Brain/Cloud Interface (2019) · cites this paper as Jackman and Regehr, 2017

    The Abstract (page not provided) says brain information processing relies on connections between neurons, and the section “Information transfer at synapses” describes synapses transmitting information to postsynaptic neurons. This supports their central role in neural processing, but the paper does not specifically characterize neurons and synapses as the fundamental electrochemical processing units of the human brain. The Introduction’s reference to a growing consensus concerns the mechanisms of long-term potentiation, not that characterization. (LLM, conf=0.82)

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Cited by

Sorted by citations

Authors
Jackman, S. L., & Regehr, W. G.
Affiliations
Harvard University (US)
Corresponding author
Regehr, Wade G.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2017-05
Volume
94
Issue
3
Pages
447-464
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2017.02.047
PMC
PMC5865607
OpenAlex
W2610396255
Cited by
489
References
8
Citations by year
2026: 51 · 2025: 58 · 2024: 73 · 2023: 50 · 2022: 65 · 2021: 66 · 2020: 38 · 2019: 40 · 2018: 40 · 2017: 8
FWCI
4.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (R01NS032405, R35NS097284)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
synaptic facilitation, short-term plasticity, synaptic transmission, neural circuit function, animal behavior, information processing
MeSH terms
Action Potentials, Animals, Calcium, Exocytosis, Synaptic Transmission, Neuromuscular Junction, Neuronal Plasticity, Neurons, Purkinje Cells, Synapses, Synaptic Vesicles

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