The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
On the Nature of a Defect in Cells from Individuals with Ataxia-Telangiectasia
Abstract
The cells and tissues of patients with ataxia-telangiectasia (A-T), an inherited disease characterized by a high degree of proneness to cancer, are abnormally sensitive to ionizing radiation. Noncycling cultures of normal human and A-T fibroblasts were exposed to x-rays so that the breakage and rejoining of prematurely condensed chromosomes in the G 1 phase could be compared. After a dose of 6.0 grays, both cell types had the same initial frequency of breaks and the same rate for rejoining of the breaks, but the fraction of breaks that did not rejoin was five to six times greater for the A-T cells. The results also show that progression of cells into the S phase is not a prerequisite for the increased frequency of chromosome fragments that appear in mitosis after A-T cells are irradiated in the G 1 or G 0 phase.
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Citations
Cites
Radiosensitivity in ataxia-telangiectasia: a new explanation.
Painter, R. B., & Young, B. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7315 · Cited by 789
Mammalian Cell Fusion : Induction of Premature Chromosome Condensation in Interphase Nuclei
JOHNSON, R. T., & RAO, P. N. (1970) · Nature · doi:10.1038/226717a0 · Cited by 701
Weisbrod, S. (1982) · Nature · doi:10.1038/297289a0 · Cited by 550
Boder, E., & Sedgwick, R. P. (1958) · PubMed · Cited by 432
Defective excision repair of γ-ray-damaged DNA in human (ataxia telangiectasia) fibroblasts
PATERSON, M. C., SMITH, B. P., LOHMAN, P. H. M., ANDERSON, A. K., & FISHMAN, L. (1976) · Nature · doi:10.1038/260444a0 · Cited by 362
Boder, E., & Sedgwick, R. P. (1958) · Pediatrics · doi:10.1542/peds.21.4.526 · Cited by 344
Survey of radiosensitivity in a variety of human cell strains.
Arlett, C. F., & Harcourt, S. A. (1980) · PubMed · Cited by 268
Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells
Houldsworth, J., & Lavin, M. F. (1980) · Nucleic Acids Research · doi:10.1093/nar/8.16.3709 · Cited by 264
Blöcher, D., & Pohlit, W. (1982) · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine · doi:10.1080/09553008214551241 · Cited by 197
X-Ray—Induced Breakage and Rejoining of Human Interphase Chromosomes
Cornforth, M. N., & Bedford, J. S. (1983) · Science · doi:10.1126/science.6648528 · Cited by 196
Self-citation
Cited by
Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226
Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2727 · Cited by 1,220
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
Lavin, M. F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2514 · Cited by 901
The many substrates and functions of ATM.
Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043058 · Cited by 779
Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
Hartwell, L. (1992) · Cell · doi:10.1016/0092-8674(92)90586-2 · Cited by 770
Metadata
- Authors
- Cornforth, M. N., & Bedford, J. S.
- Venue
- Science
- Published
- 1985-03-29
- Volume
- 227
- Issue
- 4694
- Pages
- 1589-1591
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090242035
- Cited by
- 294
- References
- 21
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
