The DOI matches its Crossref record.
X-Ray—Induced Breakage and Rejoining of Human Interphase Chromosomes
Abstract
A method was developed for the high-resolution measurement of breaks in prematurely condensed chromosomes at the G 1 phase of the cell cycle. The dose response for fragments (breaks) produced immediately after x-irradiation of confluent cultures of normal human cells was linear down to 10.9 rad (0.109 Gy) and extrapolated to zero effect at zero dose. The curve had a slope of 0.063 breaks per cell per rad, which is at least an order of magnitude greater than that for breaks scored in the same cells after they have progressed to mitosis following subculture. When incubated at 37°C half of the breaks disappeared in 2 hours. A slower, perhaps nonrejoining component was apparent at later incubation times. The initial rate of break rejoining was similar to the rate of increase in survival after incubation because of the repair of potentially lethal damage and is also in close agreement with recently reported values for the rejoining of double-strand breakage in DNA.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060
Maser, R. S., Monsen, K. J., Nelms, B. E., & Petrini, J. H. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.6087 · Cited by 499
In situ visualization of DNA double-strand break repair in human fibroblasts
Nelms, B. E., Maser, R. S., MacKay, J. F., Lagally, M. G., & Petrini, J. H. J. (1998) · Science · doi:10.1126/science.280.5363.590 · Cited by 500
Hsu, T. C., Johnston, D. A., Cherry, L. M., Ramkissoon, D., Schantz, S. P., Jessup, J. M., Winn, R. J., Shirley, L., & Furlong, C. (1989) · International Journal of Cancer · doi:10.1002/ijc.2910430310 · Cited by 313
On the Nature of a Defect in Cells from Individuals with Ataxia-Telangiectasia
Cornforth, M. N., & Bedford, J. S. (1985) · Science · doi:10.1126/science.3975628 · Cited by 294
Self-citation
Metadata
- Authors
- Cornforth, M. N., & Bedford, J. S.
- Venue
- Science
- Published
- 1983-12-09
- Volume
- 222
- Issue
- 4628
- Pages
- 1141-1143
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071850617
- Cited by
- 196
- References
- 0
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: X-Ray—Induced Breakage and Rejoining of Human Interphase Chromosomes. https://app.cochat.ai/papers/10.1126/science.6648528
- The paper
- Cornforth, M. N., & Bedford, J. S. (1983). X-Ray—Induced Breakage and Rejoining of Human Interphase Chromosomes. Science. https://doi.org/10.1126/science.6648528
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
