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A Sexually Dimorphic Nucleus in the Human Brain
Open accessAbstract
A sexually dimorphic cell group is described in the preoptic area of the human hypothalamus. Morphometric analysis revealed that the volume of this nucleus is 2.5 ± 0.6 times (mean ± standard error of the mean) as large in men as in women, and contains 2.2 ± 0.5 times as many cells. Between the ages of 10 and 93 years, the nucleus decreases greatly in volume and in cell number. Although no function has yet been established for this nucleus, it is located within an area that is essential for gonadotropin release and sexual behavior in other mammals.
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Citations
Cited by
The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia
Swaab, D. F., Fliers, E., & Partiman, T. S. (1985) · Brain Research · doi:10.1016/0006-8993(85)91350-2 · Cited by 847
Self-citationNeuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772
Hypothalamic Abnormalities in Schizophrenia: Sex Effects and Genetic Vulnerability
Goldstein, J. M., Seidman, L. J., Makris, N., Ahern, T., O’Brien, L. M., Caviness, V. S., Kennedy, D. N., Faraone, S. V., & Tsuang, M. T. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.027 · Cited by 542
A review of brain aromatase cytochrome P450
LEPHART, E. (1996) · Brain Research Reviews · doi:10.1016/0165-0173(96)00002-1 · Cited by 505
Sexual Differentiation of the Vertebrate Brain: Principles and Mechanisms
Cooke, B., Hegstrom, C. D., Villeneuve, L. S., & Breedlove, S. M. (1998) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0171 · Cited by 504
Metadata
- Authors
- Swaab, D. F., & Fliers, E.
- Venue
- Science
- Published
- 1985-05-31
- Volume
- 228
- Issue
- 4703
- Pages
- 1112-1115
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966770839
- Cited by
- 516
- References
- 0
- FWCI
- 24.48
- Type
- journal article
- Language
- en
- Open access
- green
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