Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease

Coleman, Paul D.; Flood, Dorothy G.

doi:10.1016/0197-4580(87)90127-8

Cited by 772Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease

Coleman, Paul D., Flood, Dorothy G.·1987·Neurobiology of Aging

DOI 10.1016/0197-4580(87)90127-8

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Abstract

Factors which limit the interpretation of studies of aging brain include: secular trends, species and strain differences, effects of tissue processing, and bias which may be introduced at many levels of an experimental design. With these limitations considered, evidence is reviewed regarding neuron numbers and dendritic extent in normally aging rodent, monkey and human brain and in Alzheimer's disease. It is concluded that neuron loss and change in dendritic extent in normal aging are regionally specific, and that corresponding brain regions do not always change in similar ways in rodents and primates. It is suggested that such differences may, in part, be due to inconsistent definitions of 'aged' among species. In Alzheimer's disease there is excess neuron loss and dendritic regression in some, but not all, brain regions. Measures of the morphological substrates of brain function show appreciable overlap between AD and control groups. It is hypothesized that the static, post-mortem status of brain morphology may not adequately reflect the functional capabilities of the dynamic morphology of the living brain.

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Neuron loss is a basic and fundamental feature in the pathogenesis of AD, starting already at preclinical stages when the neuropathological hallmarks are not yet present.
“Neuron loss is a basic and fundamental feature in the pathogenesis of AD [18,19], starting already at preclinical stages when the neuropathological hallmarks are not yet present [20].”
From Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models (2020) · cites this paper as [18]

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A Comparison of Cell Populations at Various Depth Levels in Cerebral Cortex of Young Adult and Aged Long-Evans Rats
Brizzee, K. R., Sherwood, N. M., & Timiras, P. S. (1968) · Journal of Gerontology · doi:10.1093/geronj/23.3.289 · Cited by 120 · see citing works
On the loss of Purkinje cells, with advancing age, from the cerebellar cortex of the albino rat
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Changes in nerve cells of the nucleus basalis of Meynert in Alzheimer's disease and their relationship to ageing and to the accumulation of lipofuscin pigment
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90140-4 · Cited by 118 · see citing works
Thioflavin S fluorescent and congo red anisotropic stainings in the histologic demonstration of amyloid
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Senescent changes in a neurobiological model system: Cerebellar Purkinje cell electrophysiology and correlative anatomy
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Neuronal Populations in the Human Brain
Konigsmark, B. W., & Murphy, E. A. (1970) · Nature · doi:10.1038/2281335a0 · Cited by 114 · see citing works
Structural Changes in the Aging Nervous System
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Distribution of altered hippocampal neurons and axons immunoreactive with antisera against neuropeptide Y in Alzheimer's‐type dementia
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Dendritic changes in the basal nucleus of meynert and in the diagonal band nucleus in Alzheimer's disease—A quantitative Golgi investigation
Arendt, T., Zveuintshva, H. G., & Lkontovich, T. A. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90141-7 · Cited by 112 · see citing works
Stability of numbers but not size of mouse forebrain cholinergic neurons to 53 months
Hornberger, J. C., Buell, S. J., Flood, D. G., McNeill, T. H., & Coleman, P. D. (1985) · Neurobiology of Aging · doi:10.1016/0197-4580(85)90003-x · Cited by 112 · see citing works
Self-citation
Age-related dendritic growth in dentate gyrus of human brain is followed by regression in the ‘oldest old’
Flood, D. G., Buell, S. J., Defiore, C. H., Horwitz, G. J., & Coleman, P. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)91018-2 · Cited by 111 · see citing works
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Atrophy of the cerebellar vermis in ageing
TORVIK, A., TORP, S. H., & Lindboe, C. F. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90176-0 · Cited by 102 · see citing works
Changes during growth in the volume and surface area of cortical neurons in the rabbit
Schadé, J. P., & Baxter, C. F. (1960) · Experimental Neurology · doi:10.1016/0014-4886(60)90005-4 · Cited by 101 · see citing works
Hypothalamic Neuron Number of Old Female Rats
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Neuronal size and density in the nucleus basalis of Meynert in Alzheimer's disease
Rinne, J. O., Paljärvi, L., & Rinne, U. K. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90260-7 · Cited by 101 · see citing works
Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4
Mani, R. B., Lohr, J. B., & Jeste, D. V. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90269-4 · Cited by 100 · see citing works
Visual evoked potentials in normal subjects and patients with multiple sclerosis
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Noradrenergic changes and memory loss in aged mice
Leslie, F. M., Loughlin, S. E., Sternberg, D. B., McGaugh, J. L., Young, L. E., & Zornetzer, S. F. (1985) · Brain Research · doi:10.1016/0006-8993(85)91439-8 · Cited by 100 · see citing works
Monoaminergic neurotransmitter systems in presenile Alzheimer's disease and in senile dementia of Alzheimer type.
Dm, M., Yates, P. O., & Marcyniuk, B. (1985) · PubMed · Cited by 100 · see citing works
Nerve Cell Loss with Aging in the Putamen
Bugiani, O., Salvarani, S., Perdelli, F., Mancardi, G., & Leonardi, A. (2008) · European Neurology · doi:10.1159/000114960 · Cited by 99 · see citing works
Catecholamine System Involvement in Age‐related Memory Dysfunction
Zornetzer, S. F. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb37594.x · Cited by 98 · see citing works
Localization of cellular changes within multimodal sensory regions in aged monkey brain: Possible implications for age-related cognitive loss☆
Brizzee, K. R., Ordy, J. M., & Bartus, R. T. (1980) · Neurobiology of Aging · doi:10.1016/0197-4580(80)90023-8 · Cited by 97 · see citing works
Senescent pathology of cerebellum: Purkinje neurons and their parallel fiber afferents
Rogers, J., Zornetzer, S. F., & Bloom, F. E. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90054-3 · Cited by 93 · see citing works
The effects of age upon the main nucleus of the inferior olive in the human
Monagle, R. D., & Brody, H. (1974) · The Journal of Comparative Neurology · doi:10.1002/cne.901550105 · Cited by 93 · see citing works
Chapter 14 Dendritic proliferation in the aging brain as a compensatory repair mechanism
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The aging human betz cell
Scheibel, M. E., Tomiyasu, U., & Scheibel, A. B. (1977) · Experimental Neurology · doi:10.1016/0014-4886(77)90323-5 · Cited by 90 · see citing works
An approach to the attribution of aging, period, and cohort effects.
Costa, P. T., & McCrae, R. R. (1982) · Psychological Bulletin · doi:10.1037/0033-2909.92.1.238 · Cited by 87 · see citing works
Neuron numbers in locus coeruleus do not change with age in fisher 344 rat
Goldman, G., & Coleman, P. D. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90056-7 · Cited by 87 · see citing works
Self-citation
Stability of synaptic density and spine volume in dentate gyrus of aged rats
Curcio, C. A., & Hinds, J. W. (1983) · Neurobiology of Aging · doi:10.1016/0197-4580(83)90058-1 · Cited by 87 · see citing works
Morphological changes in pyramidal cells of mammalian neocortex associated with increased use
Rutledge, L. T., Wright, C. G., & Duncan, J. (1974) · Experimental Neurology · doi:10.1016/0014-4886(74)90060-0 · Cited by 84 · see citing works
Neuron survival in the aging mouse
Johnson, H. A., & Erner, S. (1972) · Experimental Gerontology · doi:10.1016/0531-5565(72)90005-8 · Cited by 83 · see citing works
LHRH neurons in the female C57BL/6J mouse brain during reproductive aging: No loss up to middle age
Hoffman, G. E., & Finch, C. E. (1986) · Neurobiology of Aging · doi:10.1016/0197-4580(86)90026-6 · Cited by 81 · see citing works
Activation of vasopressin neurons in the human supraoptic and paraventricular nucleus in senescence and senile dementia
Hoogendijk, J. E., Fliers, E., Swaab, D. F., & Verwer, R. W. H. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90141-8 · Cited by 81 · see citing works
Morphological and biochemical changes in the cholinergic and monoaminergic systems in Alzheimer-type dementia
Ichimiya, Y., Arai, H., Kosaka, K., et al. (1986) · Acta Neuropathologica · doi:10.1007/bf00691428 · Cited by 81 · see citing works
Extensive loss of subcortical neurons in the aging rat brain
Sabel, B. A., & Stein, D. G. (1981) · Experimental Neurology · doi:10.1016/0014-4886(81)90284-3 · Cited by 81 · see citing works
Dendritic extent in human CA2–3 hippocampal pyramidal neurons in normal aging and senile dementia
Flood, D. G., Guarnaccia, M. M., & Coleman, P. D. (1987) · Brain Research · doi:10.1016/0006-8993(87)90744-x · Cited by 79 · see citing works
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Age-related changes in prefrontal cortex of Macaca mulatta: Synaptic density
Uemura, E. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90151-x · Cited by 78 · see citing works
Golgi-Cox and Rapid Golgi Methods as Applied to Autopsied Human Brain Tissue
Buell, S. J. (1982) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198209000-00003 · Cited by 78 · see citing works
PREDICTION OF RECOVERY IN BELL'S PALSY
Olsen, P. Z. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1975.tb01402.x · Cited by 78 · see citing works
Somatostatin- and Neuropeptide Y-immunoreactive neurons in the neocortex in senile dementia of alzheimer's type
Nakamura, S., & Vincent, S. R. (1986) · Brain Research · doi:10.1016/0006-8993(86)91099-1 · Cited by 77 · see citing works
Homeostatic Function and Aging
Halstead, H. L. (1986) · Journal of Gerontological Nursing · doi:10.3928/0098-9134-19861101-15 · Cited by 75 · see citing works
AGING OF DENDRITES IN THE CEREBRAL CORTEX OF THE MOUSE
Leuba, G. (1983) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1983.tb00130.x · Cited by 74 · see citing works
Occipital cortical morphology of the rat: Alterations with age and environment
Connor, J. R., Diamond, M. C., & Johnson, R. E. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90074-6 · Cited by 73 · see citing works
Changes in neuron number and size and glia number in the young, adult, and aging rat medial occipital cortex
Diamond, M. C., Johnson, R. E., & Gold, M. W. (1977) · Behavioral Biology · doi:10.1016/s0091-6773(77)90965-8 · Cited by 73 · see citing works
Stability of neuronal number in the human nucleus basalis of Meynert with age
Chui, H. C., Bondareff, W., Zarow, C., & Slager, U. T. (1984) · Neurobiology of Aging · doi:10.1016/0197-4580(84)90035-6 · Cited by 72 · see citing works
Neuronal RNA in Relation to Neuronal Loss and Neurofibrillary Pathology in the Hippocampus in Alzheimer's Disease
Doebler, J. A., Markesbery, W. R., Anthony, A., & Rhoads, R. E. (1987) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198701000-00003 · Cited by 71 · see citing works
A quantitative and ultrastructural study of substantia nigra and nucleus centralis superior in Alzheimer's disease
Tabaton, M., Schenone, A. E., Romagnoli, P., & Mancardi, G. (1985) · Acta Neuropathologica · doi:10.1007/bf00690198 · Cited by 69 · see citing works
Sprouting in the avian brainstem auditory pathway: Dependence on dendritic integrity
Rubel, E. W., Smith, Z. D. J., & Steward, O. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902020309 · Cited by 68 · see citing works
Stability of neuron number in cortical barrels of aging mice
Curcio, C. A., & Coleman, P. D. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120206 · Cited by 67 · see citing works
Self-citation
Cell frequencies in the human inferior olivary nuclear complex
Moatamed, F. (1966) · The Journal of Comparative Neurology · doi:10.1002/cne.901280109 · Cited by 65 · see citing works
THE LOCUS CAERULEUS IN ALZHETMERʼS DISEASE,
Forno, L. S. (1978) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197809000-00140 · Cited by 64 · see citing works
Quantitative analysis of dendritic networks of Purkinje neurons during aging
Pentney, R. J. (1986) · Neurobiology of Aging · doi:10.1016/0197-4580(86)90002-3 · Cited by 63 · see citing works
The effect of aging on the neuronal population within area 17 of adult rat cerebral cortex
Peters, A., Feldman, M. L., & Vaughan, D. W. (1983) · Neurobiology of Aging · doi:10.1016/0197-4580(83)90003-9 · Cited by 62 · see citing works
Neuronal changes in the aging mouse: Spinal cord and lower brain stem☆
Machado-Salas, J. P., Scheibel, M. E., & Scheibel, A. B. (1977) · Experimental Neurology · doi:10.1016/0014-4886(77)90253-9 · Cited by 61 · see citing works
AGE‐RELATED VARIATIONS IN THE NEURON CONTENT OF THE CEREBRAL CORTEX IN SENILE DEMENTIA OF ALZHEIMER TYPE
Hubbard, B. M., & Anderson, J. M. (1985) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1985.tb00033.x · Cited by 61 · see citing works
Aging in the rat medial nucleus of the trapezoid body I. Light microscopy
Casey, M. A., & Feldman, M. L. (1982) · Neurobiology of Aging · doi:10.1016/0197-4580(82)90039-2 · Cited by 58 · see citing works
‘NEURONAL FALL-OUT’ IN THE AGEING BRAIN: A CRITICAL REVIEW OF THE QUANTITATIVE DATA
Hanley, T. (1974) · Age and Ageing · doi:10.1093/ageing/3.3.133 · Cited by 58 · see citing works
A QUANTITATIVE HISTOLOGICAL STUDY OF NEURONAL LOSS FROM THE LOCUS COERULEUS OF AGEING MICE
Sturrock, R. R., & Rao, K. A. (1985) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1985.tb00004.x · Cited by 58 · see citing works
A preliminary quantitative study of the Purkinje cells in normal, subnormal, and senescent human cerebella, with some notes on functional localization
Ellis, R. S. (1919) · The Journal of Comparative Neurology · doi:10.1002/cne.900300204 · Cited by 57 · see citing works
A study of aging in the Human abducens nucleus
Vijayashankar, N., & Brody, H. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901730303 · Cited by 57 · see citing works
Morphologic changes in the hypothalamus of the old mouse
Machado-Salas, J. P., Scheibel, M. E., & Scheibel, A. B. (1977) · Experimental Neurology · doi:10.1016/0014-4886(77)90048-6 · Cited by 55 · see citing works
Volumes of the components of the hippocampus in the aging F344 rat
Coleman, P. D., Flood, D. G., & West, M. J. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902660213 · Cited by 55 · see citing works
Self-citation
Do vasopressin-related peptides induce hippocampal corticosterone receptors? Implications for aging
Sapolsky, R., Krey, L. C., McEwen, B., & Rainbow, T. C. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-06-01479.1984 · Cited by 54 · see citing works
Effects of aging and chronic arterial hypertension on the cell populations in the neocortex and archicortex of the rat
Knox, C. A. (1982) · Acta Neuropathologica · doi:10.1007/bf00690585 · Cited by 54 · see citing works
Age Differences in Short-Term Memory and Cell Loss in the Cortex of the Rat
Ordy, M., Brizzee, K. R., Kaack, B., et al. (2009) · Gerontology · doi:10.1159/000212260 · Cited by 54 · see citing works
Degeneration and regeneration of motoneuron dendrites after ventral root crush: Computer reconstruction of dendritic fields
Standler, N. A., & Bernstein, J. J. (1982) · Experimental Neurology · doi:10.1016/0014-4886(82)90028-0 · Cited by 52 · see citing works
No Neuron Loss from Hypothalamic Nuclei of Old Male Rats
Peng, M. T., & Hsü, H. K. (2009) · Gerontology · doi:10.1159/000212507 · Cited by 52 · see citing works
Quantitative Histological Studies on Aging Changes in Cerebral Cortex of Rhesus Monkey and Albino Rat with Notes on Effects of Prolonged Low-Dose Ionizing Irradiation in the Rat
Brizzee, K. R. (1973) · Progress in brain research · doi:10.1016/s0079-6123(08)60684-6 · Cited by 50 · see citing works
Stability of the neuronal population of the dorsal lateral geniculate nucleus (LGNd) of aged rats
Satorre, J., Cano, J., & Reinoso‐Suárez, F. (1985) · Brain Research · doi:10.1016/0006-8993(85)90108-8 · Cited by 49 · see citing works
Age-related changes in the subiculum of Macaca mulatta: Dendritic branching pattern
Uemura, E. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90172-4 · Cited by 49 · see citing works
Aging and environmental influences on two types of dendritic spines in the rat occipital cortex
Connor, J. R., Diamond, M. C., & Johnson, R. E. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90034-5 · Cited by 49 · see citing works
Aging of central endocrine neurons and their aminergic afferents
Sladek, J. R., Khachaturian, H., Hoffman, G. E., & Schöler, J. (1980) · Peptides · doi:10.1016/0196-9781(80)90112-6 · Cited by 49 · see citing works
Dendritic Changes in Aging Rat Brain: Pyramidal Cell Dendrite Length and Ultrastructure
Feldman, M. L. (1977) · Advances in behavioral biology · doi:10.1007/978-1-4684-3093-6_3 · Cited by 47 · see citing works
AUTOMATED DIFFERENTIAL CELL COUNTING ON A SECTOR OF THE NORMAL HUMAN HIPPOCAMPUS: THE INFLUENCE OF AGE
MILLER, A. K. H., Alston, R. L., Mountjoy, C. Q., & Corsellis, J. (1984) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1984.tb00344.x · Cited by 45 · see citing works
Morphological changes in the cerebellar cortex of aging Macaca nemestrina
Nandy, K. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90061-0 · Cited by 44 · see citing works
Neuron numbers in hypothalamic nuclei in young, middle-aged and aged male rats
Sartin, J. L., & Lamperti, A. A. (1985) · Cellular and Molecular Life Sciences · doi:10.1007/bf02005902 · Cited by 42 · see citing works
Aging in the rat olfactory system: Relative stability of piriform cortex contrasts with changes in olfactory bulb and olfactory epithelium
Curcio, C. A., McNelly, N. A. F., & Hinds, J. W. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902350409 · Cited by 42 · see citing works
Biomathematical analysis of the neuronal loss in the aging human brain of both sexes, demonstrated in pigment preparations of the pars cerebellaris loci coerulei
Wree, A., Braak, H., Schleicher, A., & Zilles, K. (1980) · Anatomy and Embryology · doi:10.1007/bf00315653 · Cited by 41 · see citing works
Changes in Alzheimer's disease in the magnocellular neurones of the supraoptic and paraventricular nuclei of the hypothalamus and their relationship to the noradrenergic deficit.
Dm, M., Yates, P. O., & Marcyniuk, B. (1985) · PubMed · Cited by 41 · see citing works
Aging in the human brain stem
Vijayashankar, N., & Brody, H. (1977) · Cells Tissues Organs · doi:10.1159/000144845 · Cited by 37 · see citing works
Dopaminergic neurons in the mediobasal hypothalamus of old rats: Evidence for decreased affinity of tyrosine hydroxylase for substrate and cofactor
Reymond, M. J., Arita, J., Dudley, C. A., et al. (1984) · Brain Research · doi:10.1016/0006-8993(84)90324-x · Cited by 36 · see citing works
Immunohistochemical study of the LHRH-synthesizing neuron system of aged female rats
Merchenthaler, I. J., Lengv�ri, I., Horv�th, J., et al. (1980) · Cell and Tissue Research · doi:10.1007/bf00234761 · Cited by 34 · see citing works
A Golgi study of the superficial pyramidal cells in the somatosensory cortex of socially reared old adult rats
Connor, J. R., Beban, S. E., Hopper, P. A., et al. (1982) · Experimental Neurology · doi:10.1016/0014-4886(82)90099-1 · Cited by 33 · see citing works
Preliminary report on macroscopic age changes in the human prosencephalon. A stereologic investigation.
Eggers, R., Haug, H., & Fischer, D. (1984) · PubMed · Cited by 32 · see citing works
THE INFLUENCE OF AGE AND DEMENTIA ON THE NEURONE POPULATION OF THE MAMMILLARY BODIES
Wilkinson, A., & Davies, I. (1978) · Age and Ageing · doi:10.1093/ageing/7.3.151 · Cited by 31 · see citing works
The effect of increased longevity, produced by dietary restriction, on the neuronal population of area 17 in rat cerebral cortex
Peters, A., Harriman, K. M., & West, C. D. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90052-2 · Cited by 30 · see citing works
Stability of dendrites in cortical barrels of C57BL/6N mice between 4 and 45 months
Coleman, P. D., Buell, S. J., Magagna, L., et al. (1986) · Neurobiology of Aging · doi:10.1016/0197-4580(86)90147-8 · Cited by 30 · see citing works
Self-citation
A golgi study of dendritic morphology in the occipital cortex of socially reared aged rats
Connor, J. R., Connor, J. R., Diamond, M. C., et al. (1981) · Experimental Neurology · doi:10.1016/0014-4886(81)90286-7 · Cited by 30 · see citing works
Synaptic changes in the hypothalamic arcuate nucleus of old male rats
Matsumoto, A., Okada, R., & Arai, Y. (1982) · Experimental Neurology · doi:10.1016/0014-4886(82)90076-0 · Cited by 29 · see citing works
Limbic system of the aged mouse
Machado-Salas, J. P., & Scheibel, A. B. (1979) · Experimental Neurology · doi:10.1016/0014-4886(79)90130-4 · Cited by 29 · see citing works
The evaluation of cell-densities and of nerve-cell-size distribution by stereological procedures in a layered tissue (cortex cerebri).
Haug, H. (1979) · PubMed · Cited by 28 · see citing works
The importance of video editing in automated image analysis in studies of the cerebral cortex
Terry, R. D., & DeTeresa, R. M. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90239-8 · Cited by 27 · see citing works
The volume of the neocortex of the albino rat and the changes it undergoes with age after birth
Smith, C. G. (1934) · The Journal of Comparative Neurology · doi:10.1002/cne.900600209 · Cited by 26 · see citing works
Quantitative studies in ageing Chbb:THOM (Wistar) rats. II. Neuron numbers in lobules I, VIb + c and X.
Drüge, H., Heinsen, H., & Yl, H. (1986) · PubMed · Cited by 22 · see citing works
Neuropeptides in Alzheimer's disease: A review and morphological results
Bouras, C., Hilaire-Kafi, S. D. S., & Constantinidis, J. (1986) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(86)90007-2 · Cited by 20 · see citing works
Changes in Cell Density within the Human Hippocampal Formation as a Function of Age
Devaney, K. O., & Johnson, H. A. (2009) · Gerontology · doi:10.1159/000212615 · Cited by 16 · see citing works
IMMUNOCYTOCHEMICAL LOCALIZATION OF ENKEPHALIN‐LIKE IMMUNOREACTIVITY IN NEURONS OF HUMAN HIPPOCAMPAL FORMATION: EFFECTS OF AGEING AND ALZHEIMER'S DISEASE
Kulmala, H. K. (1985) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1985.tb00008.x · Cited by 16 · see citing works
Registrar's corner acute pancreatitis: updated.
Swaab, D. F., Fliers, E., & Fisser, B. (1985) · PubMed · Cited by 16 · see citing works
Diencephalic catecholamine neurons (A‐11, A‐12, A‐13, A‐14) show divergent changes in the aged rat
Selemon, L. D., & Sladek, J. R. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902540110 · Cited by 14 · see citing works
quantitative analysis
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Cell death during development of the nervous system
Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084 · see citing works
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796 · see citing works
“Controversy also exists about whether aging and AD represent a neuropathological continuum or are dichotomous (Terry et al., 1981, 1987; Coleman and Flood, 1987; West et al., 1994).”
Background
Life and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344 · see citing works
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · see citing works
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Authors: Coleman, P. D., & Flood, D. G.
Affiliations: University of Rochester Medicine (US)
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1987-11
Volume: 8
Issue: 6
Pages: 521-545
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/0197-4580(87)90127-8
OpenAlex: W1966157184
Cited by: 772
References: 203
Citations by year: 2026: 3 · 2025: 4 · 2024: 10 · 2023: 15 · 2022: 7 · 2021: 10 · 2020: 15 · 2019: 13 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 15 · 2014: 10 · 2013: 16 · 2012: 11
FWCI: 5.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG01121, AG03644)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neuronal loss, normal brain aging, Alzheimer's disease, rodent brain, primate brain
MeSH terms: Aging, Alzheimer Disease, Amygdala, Animals, Brain, Cerebellum, Cerebral Cortex, Dendrites, Hippocampus, Humans, Neurons, Species Specificity

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Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease

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