The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Watching Fat Digestion: The formation of visible product phases by pancreatic lipase is described.
Abstract
During fat digestion a number of physicochemical events can be seen directly by light microscopy. Under simulated physiological conditions, hydrolysis of emulsified fat droplets by human pancreatic lipase in the presence of colipase and bile salt micelles proceeds with the sequential formation of two visible product phases. A lamellar liquid crystalline or crystalline phase containing calcium and ionized fatty acid forms first; this is followed by the production of a "viscous isotropic" phase composed predominantly of monoglycerides and protonated fatty acids.
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Citations
Cites
Studies of Intestinal Digestion and Absorption in the Human1
Borgström, B., Dahlqvist, A., Lundh, G., & Sjövall, J. (1957) · Journal of Clinical Investigation · doi:10.1172/jci103549 · Cited by 1,048
Carey, M. C., & Small, D. M. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109025 · Cited by 699
Self-citationHofmann, A. F., & Borgström, B. (1964) · Journal of Clinical Investigation · doi:10.1172/jci104909 · Cited by 443
Physico-chemical state of lipids in intestinal content during their digestion and absorption.
Hofmann, A. F., & Borgström, B. (1962) · PubMed · Cited by 314
A classification of biologic lipids based upon their interaction in aqueous systems
Small, D. M. (1968) · Journal of the American Oil Chemists' Society · doi:10.1007/bf02915334 · Cited by 257
Borgström, B. (1975) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34490-4 · Cited by 179
Preparation and properties of vesicles enclosed by fatty acid membranes
Gebicki, J. M., & Hicks, M. (1976) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(76)90006-2 · Cited by 165
THE DIGESTION IN VITRO OF TRIGLYCERIDES BY PANCREATIC LIPASE
Mattson, F. H., & Beck, L. W. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70949-6 · Cited by 152
On the mechanism of pancreatic lipolysis of glycerides
Borgström, B. (1954) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(54)90365-0 · Cited by 144
Lipase and Co-lipase Activities of Human Small Intestinal Contents after a Liquid Test Meal
Borgström, B., & Hildebrand, H. (1975) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1975.12097016 · Cited by 91
Cited by
Lipids and Lipid-Based Formulations: Optimizing the Oral Delivery of Lipophilic Drugs
Porter, C. J. H., Trevaskis, N. L., & Charman, W. N. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2197 · Cited by 1,824
50 years of oral lipid-based formulations: provenance, progress and future perspectives
Feeney, O. M., Crum, M. F., McEvoy, C. L., Trevaskis, N. L., Williams, H. D., Pouton, C. W., Charman, W. N., Bergström, C. A. S., & Porter, C. J. H. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.007 · Cited by 426
Calcium bioavailability and absorption: a review
Allen, L. (1982) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/35.4.783 · Cited by 373
Interfacial & colloidal aspects of lipid digestion
Wilde, P. J., & Chu, B. S. (2011) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2011.02.004 · Cited by 334
Sek, L., Porter, C. J. H., Kaukonen, A. M., & Charman, W. N. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021771896 · Cited by 304
Metadata
- Authors
- Patton, J. S., & Carey, M. C.
- Venue
- Science
- Published
- 1979-04-13
- Volume
- 204
- Issue
- 4389
- Pages
- 145-148
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082502730
- Cited by
- 384
- References
- 17
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
