The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Dendritic Mechanisms Underlying Penicillin-Induced Epileptiform Activity
Abstract
The action of penicillin on synaptically evoked dendritic activity was examined with the use of hippocampal slice preparations. Orthodormic activation of CA1 pyramidal neurons produced an excitatory-inhibitory postsynaptic potential sequence recorded intracellularly in the dendrites. Treatment with penicillin resulted in the appearance of spontaneous and synaptically evoked multipeaked field potentials and associated depolarization shifts and spike burst generation in CA1 cells. Intracellular recordings revealed that penicillin produced no detectable change in passive membrane properties of the postsynaptic dendrites. However, the inhibitory postsynaptic potential was suppressed by penicillin, resulting in the release of intrinsic dendritic burst firing during synaptic activation. These findings emphasize the role of normal patterns of dendritic burst generation in the production of intense neuronal discharge during penicillin-induced epileptiform activities.
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Citations
Cites
Unit analysis of hippocampal population spikes
Andersen, P., Bliss, T. V. P., & Skrede, K. K. (1971) · Experimental Brain Research · doi:10.1007/bf00234086 · Cited by 606
Intradendritic recordings from hippocampal neurons.
Wong, R. K., Prince, D. A., & Basbaum, A. I. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.2.986 · Cited by 551
Self-citationCharacteristics of CA1 neurons recorded intracellularly in the hippocampalin vitro slice preparation
Schwartzkroin, P. A. (1975) · Brain Research · doi:10.1016/0006-8993(75)90817-3 · Cited by 505
Structure and Function of Synapses.
(1972) · Archives of Neurology · doi:10.1001/archneur.1972.00490160092019 · Cited by 439
Cellular and field potential properties of epileptogenic hippocampal slices
Schwartzkroin, P. A., & Prince, D. A. (1978) · Brain Research · doi:10.1016/0006-8993(78)90776-x · Cited by 433
Self-citationPrince, D. A. (1978) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.01.030178.002143 · Cited by 392
Self-citationDichter, M., & Spencer, W. A. (1969) · Journal of Neurophysiology · doi:10.1152/jn.1969.32.5.663 · Cited by 365
The transverse hippocampal slice: a well-defined cortical structure maintainedin vitro
Skrede, K. K., & Westgaard, R. H. (1971) · Brain Research · doi:10.1016/0006-8993(71)90508-7 · Cited by 293
MACDONALD, R. L., & BARKER, J. L. (1977) · Nature · doi:10.1038/267720a0 · Cited by 259
Activation of hippocampal neurons by mossy fiber stimulation in thin brain sections in vitro
Yamamoto, C. (1972) · Experimental Brain Research · doi:10.1007/bf00235037 · Cited by 245
Cited by
Feed‐forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro
Alger, B. E., & Nicoll, R. A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014255 · Cited by 527
Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic transmission
Jefferys, J. G. R., & Haas, H. L. (1982) · Nature · doi:10.1038/300448a0 · Cited by 431
Alger, B. E., & Nicoll, R. A. (1980) · Science · doi:10.1126/science.7444438 · Cited by 425
Changes in excitatory and inhibitory synaptic potentials leading to epileptogenic activity
Schwartzkroin, P. A., & Prince, D. A. (1980) · Brain Research · doi:10.1016/0006-8993(80)90119-5 · Cited by 314
Self-citationDingledine, R. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014899 · Cited by 288
Metadata
- Authors
- Wong, R. K. S., & Prince, D. A.
- Venue
- Science
- Published
- 1979-06-15
- Volume
- 204
- Issue
- 4398
- Pages
- 1228-1231
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005273920
- Cited by
- 314
- References
- 15
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
