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Epileptiform Burst Afterhyperpolarization: Calcium-Dependent Potassium Potential in Hippocampal CA1 Pyramidal Cells
Abstract
Synaptic excitation of hippocampal cells during blockade of synaptic inhibition results in an epileptiform "burst" potential followed by a prolonged afterhyperpolarization. This afterhyperpolarization resembles the one that is seen after the epileptic interictal spike and that is considered of critical importance in preventing seizure development. The afterhyperpolarization produced in the presence of γ-aminobutyric acid antagonists is associated with a conductance increase and is inhibitory. It can occur in an all-or-none fashion after a burst, is independent of chloride, and is depressed by barium. The afterhyperpolarization has a reversal potential of -86 millivolts, and the reversal potential is strongly dependent on the extracellular concentration of potassium. The afterhyperpolarization appears to be an intrinsic, inhibitory potassium potential mediated by calcium. This finding has implications for understanding the cellular mechanisms of epilepsy.
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Citations
Cites
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons
Hotson, J. R., & Prince, D. A. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.2.409 · Cited by 569
Cited by
Llinás, R. R. (1988) · Science · doi:10.1126/science.3059497 · Cited by 2,285
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983) · Nature · doi:10.1038/305719a0 · Cited by 1,116
Hippocampal sharp waves: Their origin and significance
Buzsáki, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)91483-6 · Cited by 925
Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro.
Madison, D. V., & Nicoll, R. A. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015378 · Cited by 746
Self-citationChapter 12 Potassium currents in hippocampal pyramidal cells
Storm, J. F. (1990) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61248-0 · Cited by 743
Metadata
- Authors
- Alger, B. E., & Nicoll, R. A.
- Venue
- Science
- Published
- 1980-12-05
- Volume
- 210
- Issue
- 4474
- Pages
- 1122-1124
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036686141
- Cited by
- 425
- References
- 1
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Alger, B. E., & Nicoll, R. A. (1980). Epileptiform Burst Afterhyperpolarization: Calcium-Dependent Potassium Potential in Hippocampal CA1 Pyramidal Cells. Science. https://doi.org/10.1126/science.7444438
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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