Cocaine: plasma concentrations after intranasal application in man.
Abstract
Cocaine (1.5 milligrams per kilogram) was applied to the nasal mucosa of human subjects. The cocaine persisted in the plasma for 4 to 6 hours and reached peak concentrations of 120 to 474 nanograms per milliliter at 15 to 60 minutes. In that residual cocaine was detectable on the nasal mucosa for 3 hours, continuous absorption secondary to its vasoconstrictive action might explain its persistence in the plasma.
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Plasma levels of cocaine in humans who inhale cocaine intranasally range between 0.4 and 1.6 μM.
“It has been shown that the plasma levels of cocaine in humans who inhale cocaine intranasally ranges between 0.4 and 1.6 μM (Van Dyke et al., 1976) while the plasma cocaine levels in tolerant abusers was found to be 13 μM (Stephens et al., 2004).”
From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Van Dyke et al., 1976
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- Authors
- Van Dyke, C., Barash, P. G., Jatlow, P., & Byck, R.
- Affiliations
- Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510
- Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510
- Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
- Venue
- Science
- Published
- 1976-02-27
- Volume
- 191
- Issue
- 4229
- Pages
- 859-861
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 168
- References
- 0
- Language
- en
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